2022 College Football Week 11 Odds, Overview & Picks

By Hank Blaine

The Ohio State Buckeyes hope to maintain their top four College Football Playoff ranking on Saturday when the Buckeyes host the Indiana Hoosiers a close to 40-point favorite. Ohio State versus Indiana is just one of the top games happening in what promises to be an exciting College Football Week 11.

Before everything else, NitroBetting arms you with everything you need to kick things off on a positive note. Below, we provide event details, team and player statistics, and the latest College Football odds. More than that, we go the extra mile and share timely betting trends and predictions that help you secure the best picks. Check out for more sports betting odds and lines, exclusively at our online BTC sportsbook.

Top 2022 College Football Week 11 Games to Bet

Colorado Buffaloes vs. USC Trojans

  • When: Friday, November 11th, 2022. 9:30pm EST.
  • Where: Los Angeles Memorial Coliseum, Los Angeles, CA
  • College Football Odds: Colorado (+34) // USC (-34)

At first glance the spread line seems out of whack. A closer look, though, reveals Colorado is one of the worst teams, maybe the worst, in the nation.

The Buffaloes are 1-8 SU and 2-7 against the spread. In their last, Oregon blasted the Buffs 49- 10. USC averages 41 points per. So the Trojans should cover.

2022 College Football Week 11 Pick: USC

Purdue Boilermakers vs. Illinois Fighting Illini

  • When: Saturday, November 12th, 2022. 12:00pm EST.
  • Where: Memorial Stadium, Champaign, IL
  • College Football Odds: Purdue (+6.5) // Illinois (-6.5)

Purdue has fallen on hard times. The Boilermakers have lost 2 straight and are 0-3 against the spread in their last 3.

Illinois fell to Michigan State in their last. Expect the Illini to bounce back in this. Illinois allows around 10 points per game on average, ranking first in the nation.

2022 College Football Week 11 Pick: Illinois

Missouri Tigers vs. Tennessee Volunteers

  • When: Saturday, November 12th, 2022. 12:00pm EST.
  • Where: Neyland Stadium, Knoxville, TN
  • College Football Odds: Missouri (+20) // Tennessee (-20)

The Tigers have played well but on Saturday, Mizzou faces a Volunteers’ squad looking to bounce back after a road loss against rival Georgia. Tennessee figures to go no holds barred versus overmatched Missouri, which means laying the -20.5 is the way to go.

2022 College Football Week 11 Pick: Illinois

Indiana Hoosiers vs. Ohio State Buckeyes

  • When: Saturday, November 12th, 2022. 12:00pm EST.
  • Where: Ohio Stadium, Columbus, OH
  • College Football Odds: Indiana (+40) // Ohio State (-40)

Think twice before taking the 39.5 points on Indiana. The Hoosiers allow over 32 points on average while Ohio State scores 45.8 per.

Ohio State beat Iowa by 44, Rutgers by 39, and Michigan State by 29. Indiana has an okay offense. But OSU will try to score a TD on every possession because they only scored 21 versus Northwestern in their last. Buckeyes cover.

2022 College Football Week 11 Pick: Ohio State

Nebraska Cornhuskers vs. Michigan Wolverines

  • When: Saturday, November 12th, 2022. 3:30pm EST.
  • Where: Michigan Stadium, Ann Arbor, MI
  • College Football Odds: Nebraska (+31) // Michigan (-31)

The Wolverines have covered in 3 straight and 4-of-5. Michigan beat Rutgers 52-17 in their last.

So if the Wolverines can cover a 26-point spread against the Scarlet Knights, they can definitely cover a -30.5 spread versus Nebraska. The Huskers are 3-6 ATS, which adds to the Michigan covering thesis.

2022 College Football Week 11 Pick: Michigan

Maryland Terrapins vs. Penn State Nittany Lions

  • When: Saturday, November 12th, 2022. 3:30pm EST.
  • Where: Beaver Stadium, University Park, PA
  • College Football Odds: Maryland (+31) // Penn State (-31)

6-3 straight up Maryland is 4-5 against the spread. The Terps are on a 4-game spread losing streak.

Penn State has covered in 3 straight and routed Indiana 45-14 in their last. The Nittany Lions get another win and cover.

2022 College Football Week 11 Pick: Penn State

Louisville Cardinals vs. Clemson Tigers

  • When: Saturday, November 12th, 2022. 3:30pm EST.
  • Where: Memorial Stadium, Clemson, SC
  • College Football Odds: Louisville (+7.5) // Clemson (-7.5)

Coming off their first loss of the season, Clemson hopes to move up in the College Football Rankings by beating Louisville.

But the Cardinals are hot. Louisville has won 4 straight up and against the spread. The victories were versus quality opponents Virginia, Pittsburgh, Wake Forest, and James Madison. The Cardinals will have a shot to win this game.

2022 College Football Week 11 Pick: Louisville

Washington Huskies vs. Oregon Ducks

  • When: Saturday, November 12th, 2022. 7:00pm EST.
  • Where: Autzen Stadium, Eugene, OR
  • College Football Odds: Washington (+13) // Oregon (-13)

After starting the season going 4-0 SU and ATS, Washington has since lost 2 games straight up. The Huskies have lost 5 straight against the spread.

Oregon has won 8 straight SU and 5 straight ATS. The Ducks are a legit College Football Playoff contender. Oregon requires luck to get into the top four, but it could happen. Expect the Ducks to blow out their rivals.

2022 College Football Week 11 Pick: Oregon

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*All stated odds are subject to change without prior notice.

READ MORE: 2022 College Football Week 12 Odds, Overview & Picks