2022 College Football Week 12 Odds, Overview & Picks

By Hank Blaine

Week 12 is the second to final in the 2022 NCAAF Regular Season. This Saturday, Big 12 Championship participant TCU hopes to continue their undefeated record by beating 2021 conference champion Baylor, first-ranked Georgia heads to Kentucky hoping to prevent a trap game loss, and Ohio State takes on the Terrapins in Maryland.

Before everything else, NitroBetting arms you with everything you need to kick things off on a positive note. Below, we provide event details, team and player statistics, and the latest College Football odds. More than that, we go the extra mile and share timely betting trends and predictions that help you secure the best picks. Check out for more sports betting odds and lines, exclusively at our online BTC sportsbook.

Top 2022 College Football Week 12 Games to Bet

TCU Horned Frogs vs. Baylor Bears

  • When: Saturday, November 19th, 2022. 12:00pm EST.
  • Where: McLane Stadium, Waco, TX
  • College Football Odds: TCU (+34) // Baylor (-34)

This is a much bigger game than many realize. Baylor is 6-4, a game behind Kansas State and Oklahoma State, both at 7-3.

Kansas State is 5-2 in the conference. So the Wildcats, who beat the Bears, would have to lose their next 2 games for Baylor to have a shot. Crazier things have happened. For TCU, the stakes are even higher. Sure, the Horned Frogs will play in the Big 12 title game.

But Texas Christian wants a chance to win the National Championship. Baylor hosts TCU a +2.5 underdog. The Horned Frogs have done everything right this season, including beating Texas straight up as a +7 dog last Saturday. There’s no reason to jump off the Frogs’ bandwagon this late in the season.

2022 College Football Week 12 Pick: TCU

Georgia Bulldogs vs. Kentucky Wildcats

  • When: Saturday, November 19th, 2022. 3:30pm EST.
  • Where: Kroger Field, Lexington, KY
  • College Football Odds: Georgia (-22.5) // Kentucky (+22.5)

This is a much bigger game than many realize. Baylor is 6-4, a game behind Kansas State and Oklahoma State, both at 7-3.

Kansas State is 5-2 in the conference. So the Wildcats, who beat the Bears, would have to lose their next 2 games for Baylor to have a shot. Crazier things have happened. For TCU, the stakes are even higher. Sure, the Horned Frogs will play in the Big 12 title game.

But Texas Christian wants a chance to win the National Championship. Baylor hosts TCU a +2.5 underdog. The Horned Frogs have done everything right this season, including beating Texas straight up as a +7 dog last Saturday. There’s no reason to jump off the Frogs’ bandwagon this late in the season.

2022 College Football Week 12 Pick: Kentucky

Ohio State Buckeyes vs. Maryland Terrapins

  • When: Saturday, November 19th, 2022. 3:30pm EST.
  • Where: SECU Stadium, College Park, MD
  • College Football Odds: Ohio State (-27.5) // Maryland (+27.5)

Ohio State must be careful looking forward to next Saturday’s showdown with Michigan. Also, Ohio State has gone 1-2 against the spread in their last 3.

But Penn State shut out Maryland and scored 30. The Buckeyes should at least match the Nittany Lions’ victory margin.

2022 College Football Week 12 Pick: Ohio State

Miami Hurricanes vs. Clemson Tigers

  • When: Saturday, November 19th, 2022. 3:30pm EST.
  • Where: SECU Stadium, College Park, MD
  • College Football Odds: Ohio State (-27.5) // Maryland (+27.5)

Mario Cristobal’s first season as Miami coach has not gone as planned. The Canes are 5-5 straight up and 2-8 against the spread. Clemson beat Louisville, a better team than Miami, 31-16 in their last. This happens in Death Valley. Clemson should have no trouble covering.

2022 College Football Week 12 Pick: Clemson

Tennessee Volunteers vs. South Carolina Gamecocks

  • When: Saturday, November 19th, 2022. 7:00pm EST.
  • Where: Williams-Brice Stadium, Columbia, SC
  • College Football Odds: Tennessee (-27.5) // South Carolina (+27.5)

How did Tennessee follow up the 27-13 loss to Georgia? All the Vols did, and the reason they rank fifth in the nation, is blast Missouri 66-24. South Carolina allows over 26 points per game and hosts Tennessee a week after falling to Florida 38-3. Vols Roll.

2022 College Football Week 12 Pick: Tennessee

Ole Miss Rebels vs. Arkansas Razorbacks

  • When: Saturday, November 19th, 2022. 7:30pm EST.
  • Where: Razorback Stadium, Fayetteville, AR
  • College Football Odds: Ole Miss (-2.5) // Arkansas (+2.5)

How did Tennessee follow up the 27-13 loss to Georgia? All the Vols did, and the reason they rank fifth in the nation, is blast Missouri 66-24. South Carolina allows over 26 points per game and hosts Tennessee a week after falling to Florida 38-3. Vols Roll.

2022 College Football Week 12 Pick: Tennessee

Ole Miss Rebels vs. Arkansas Razorbacks

  • When: Saturday, November 19th, 2022. 7:30pm EST.
  • Where: Razorback Stadium, Fayetteville, AR
  • College Football Odds: Ole Miss (-2.5) // Arkansas (+2.5)

Mississippi faced Alabama in their last. The Rebels lost the game, but they covered by 4.5 points. On Saturday, Lane Kiffin’s bunch heads to Arkansas to take on the Razorbacks.

The Hogs couldn’t get it done versus LSU but the Hogs played great football in the 13-10 loss. KJ Jefferson should play. So Arkansas is the pick.

2022 College Football Week 12 Pick: Arkansas

Oklahoma State Cowboys vs. Oklahoma Sooners

  • When: Saturday, November 19th, 2022. 7:30pm EST.
  • Where: Memorial Stadium, Norman, OK
  • College Football Odds: Oklahoma State (+7.5) // Oklahoma (-7.5)

Once in a while, Oklahoma State can throw in a clunker. But let’s be real. No way Oklahoma should be a -7.5 points favorite versus the Pokes.

The Sooners have lost their last 2 straight up as the chalk, to Baylor and West Virginia, and are 3-7 ATS on the season. The Pokes can win this one straight up. Taking the points is the more conservative play.

2022 College Football Week 12 Pick: Oklahoma State

USC Trojans vs. UCLA Bruins

  • When: Saturday, November 19th, 2022. 8:00pm EST.
  • Where: Rose Bowl, Pasadena, CA
  • College Football Odds: USC (-2.5) // UCLA (+2.5)

One of the fiercest rivalries in college football resumes on Saturday when the UCLA Bruins host the UCLA Trojans at the Rose Bowl in Pasadena.

Both teams are having good season. UCLA’s got worse when the Bruins couldn’t beat the Arizona Wildcats last week. The reason for the poor showing could have something to do with looking ahead to this game.

USC is 9-1 straight up. The only loss happened against Utah on the road by a single point. USC should punish a UCLA defense whose smoke has dissipated and whose mirror has cracked.

2022 College Football Week 12 Pick: USC

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*All stated odds are subject to change without prior notice.

READ MORE: 2022 College Football Week 13 Odds, Overview & Picks