2022 College Football Week 13 Odds, Overview & Picks

By Hank Blaine

It’s rivalry week in college football. Top matchups start on Friday night when Baylor heads to Austin to take on the Texas Longhorns. Then on Saturday, 5-LSU hopes to prevent an upset loss to Texas A&M and 5-LSU faces a stiff test in Texas A&M.

Before everything else, NitroBetting arms you with everything you need to kick things off on a positive note. Below, we provide event details, team and player statistics, and the latest College Football odds. More than that, we go the extra mile and share timely betting trends and predictions that help you secure the best picks. Check out for more sports betting odds and lines, exclusively at our online BTC sportsbook.

Top 2022 College Football Week 13 Games to Bet

Baylor Bears vs. Texas Longhorns

  • When: Friday, November 25th, 2022. 12:00pm EST.
  • Where: DKR-Texas Memorial Stadium, Austin, TX
  • College Football Odds: Baylor (+8.5) // Texas (-8.5)

Even though the Longhorns are just 7-4 against the spread, oddsmakers continue to show Texas the love. No way the Horns should be -8.5 favorites versus the Bears.

Baylor lost by a single point to TCU in their last. Not only that, but outside of an inexplicable 31-3 defeat versus Kansas State, the Bears have rocked, going 4-1 ATS in their last 5.

2022 College Football Week 13 Pick: Baylor

NC State Wolfpack vs. North Carolina Tar Heels

  • When: Friday, November 25th, 2022. 3:30pm EST.
  • Where: Kenan Stadium, Chapel Hill, NC
  • College Football Odds: NC State (+6.5) // North Carolina (-6.5)

NC State has the defense. North Carolina will field the offense. The Tar Heels average 38 points per game.

But UNC also allows 30 per contest. NC State allows less than 19 each game. The Wolfpack’s D makes NC State the play.

2022 College Football Week 13 Pick: NC State

Florida Gators vs. Florida State Seminoles

  • When: Friday, November 25th, 2022. 7:30pm EST.
  • Where: Doak Campbell Stadium, Tallahassee, FL
  • College Football Odds: Florida (+9.5) // FSU (-9.5)

The Gators committed the ultimate SEC sin. No SEC football program should ever lose to the Vanderbilt Commodores. Not only did Florida fall to Vandy in their last, but they lost after allowing the Commodores to score 41 points.

FSU is on a 4-game SU and ATS streak where they’ve scored 24, 45, 38, and 49. The Seminoles are playing lights out right now and this happens in Tallahassee.

2022 College Football Week 13 Pick: FSU

South Carolina Gamecocks vs. Clemson Tigers

  • When: Saturday, November 26th, 2022. 12:00pm EST.
  • Where: Memorial Stadium, Clemson, SC
  • College Football Odds: South Carolina (+14.5) // Clemson (-14.5)

South Carolina quarterback Spencer Rattler went crazy against the Tennessee Volunteers. Rattler threw for 438 yards and tossed 6 TD passes.

Clemson’s defense is good, but it’s not that good. If this ends up a shootout, South Carolina will have the better quarterback, so, taking the points is the way to go.

2022 College Football Week 13 Pick: FSU

Auburn Tigers vs. Alabama Crimson Tide

  • When: Saturday, November 26th, 2022. 3:30pm EST.
  • Where: Bryant-Denny Stadium, Tuscaloosa, AL
  • College Football Odds: Auburn (+22) // Alabama (-22)

Auburn has an interim coach, but that shouldn’t dissuade us from backing the Tigers. Auburn always plays Alabama tough. It doesn’t matter who coaches, who is the quarterback, where the game happens, etc.

In this case, Bama is 1-5 ATS in their last 6 and Auburn is 4-1 ATS in their last 5. So in this rendition of the Iron Bowl, the Tigers are the play against the spread.

2022 College Football Week 13 Pick: Auburn

Michigan State Spartans vs. Penn State Nittany Lions

  • When: Saturday, November 26th, 2022. 4:00pm EST.
  • Where: Beaver Stadium, University Park, PA
  • College Football Odds: Michigan State (+19) // Penn State (-19)

Sparty is 1-3 ATS in their last 4. Michigan State has played okay but it hasn’t been good enough for many spread line victories.

Penn State has won 5 straight against the spread. The Nittany Lions have won 4-of-5 with the only loss happening against 2-ranked Ohio State. Lions roar.

2022 College Football Week 13 Pick: Penn State

Iowa State Cyclones vs. TCU Horned Frogs

  • When: Saturday, November 26th, 2022. 4:00pm EST.
  • Where: Amon G. Carter Stadium, Fort Worth, TX
  • College Football Odds: Iowa State (+10) // TCU (-10)

Iowa State has a great defense, but the Cyclones’ offense won’t produce enough points in this game to touch 4-ranked TCU. The Horned Frogs understand what’s at stake if they lose this game.

So we should expect TCU to dominate on the scoreboard. Horned Frogs enter next Saturday’s Big 12 title contest with an undefeated record.

2022 College Football Week 13 Pick: TCU

LSU Tigers vs. Texas A&M Aggies

  • When: Saturday, November 26th, 2022. 7:00pm EST.
  • Where: Kyle Field, College Station, TX
  • College Football Odds: LSU (-5) // Texas A&M (+5)

LSU knows they have stamped their ticket for next Saturday’s SEC Championship, which is why this game will present a challenge. The Aggies play LSU tough every season. So we shouldn’t expect A&M to produce a half-hearted effort like they have in recent games.

The Tigers will win. Covering the spread is another story. Jimbo Fisher’s team will play to the final whistle and put a scare into the nation’s fifth-ranked squad.

2022 College Football Week 13 Pick: Texas A&M

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*All stated odds are subject to change without prior notice.

READ MORE: 2022 College Football Week 14 Odds, Overview & Picks