2022 College Football Week 3 Odds, Overview & Picks

By Hank Blaine

NCAAF Week 3 actions starts on Friday when Florida State takes on Louisville on the road in an ACC showdown. Then on Saturday, a classic matchup happens when Oklahoma travels to Nebraska. Also on Saturday, Pac 12 power Oregon hopes to get back on track versus 13-ranked BYU, Georgia Tech hosts Ole Miss, and Penn State travels to Alabama to take on the Auburn Tigers. Saturday’s top matchup pits the 24-ranked Texas A&M Aggies against 13-Miami.

Before everything else, NitroBetting arms you with everything you need to kick things off on a positive note. Below, we provide event details, team and player statistics, and the latest NCAAF odds. More than that, we go the extra mile and share timely betting trends and predictions that help you secure the best picks. Check out for more sports betting odds and lines, exclusively at our online BTC sportsbook.

Top 2022 College Football Week 3 Games to Bet

Florida State Seminoles vs. Louisville Cardinals

  • When: Friday, September 16th, 2022. 7:30pm EST.
  • Where: Cardinal Stadium, Louisville, KY
  • College Football Odds: FSU (-3) // Louisville (+3)

Florida State played great in their first game. The Seminoles upset a talented LSU team in New Orleans, which means FSU beat Louisiana State on the road.

But although FSU will challenge for the win in this, beating a solid Louisville team led by veteran quarterback Malik Cunningham won’t be easy. Louisville got on track with a fantastic 20-17 road win over UCF in their last. Louisville covers.

2022 College Football Week 3 Pick: Louisville

Oklahoma Sooners vs. Nebraska Cornhuskers

  • When: Saturday, September 17th, 2022. 12:00pm EST.
  • Where: Memorial Stadium, Lincoln, NE
  • College Football Odds: Oklahoma (-10) // Nebraska (+10)

Wow. Nebraska is bad. After 2 losses in their first 3 games, including an embarrassing home loss to Georgia Southern, the Cornhuskers fired legendary Nebraska player turned coach Scott Frost. Nebraska heads into this game with an interim coach.

Oklahoma is going about their business dominating opponents. Central Florida transfer Dillon Gabriel has thrown for a combined 529 yards and tossed 5 touchdowns without a pick in wins against UTEP and Kent State. One would think Nebraska would be more of a challenge. But the Cornhuskers will require a gargantuan effort to keep this close. Oklahoma rolls.

2022 College Football Week 3 Pick: Oklahoma

BYU Cougars vs. Oregon Ducks

  • When: Saturday, September 17th, 2022. 3:30pm EST.
  • Where: Autzen Stadium, Eugene, OR
  • College Football Odds: BYU (+3.5) // Oregon (-3.5)

After the 49-3 loss versus Georgia, many put a fork into Oregon. But the Ducks bounced back with a nice 70-14 win against Eastern Washington. Oregon isn’t as bad as they showed versus Georgia. But they’re also not as good as they showed against Eastern Washington. BYU outlasted Baylor in an overtime classic in their last. The Cougars should carry momentum into this game. The Cougs get the nod.

2022 College Football Week 3 Pick: BYU

Ole Miss Rebels vs. Georgia Tech Yellow Jackets

  • When: Saturday, September 17th, 2022. 3:30pm EST.
  • Where: Bobby Dodd Stadium, Atlanta, GA
  • College Football Odds: Ole Miss (-16.5) // Georgia Tech (+16.5)

Ole Miss is undefeated after a couple of wins. However, the betting line on the Rebels is inflated. It’s not that Mississippi isn’t a good team. But beating Troy and Central Arkansas doesn’t mean Ole Miss can beat Georgia Tech by 17 points on the road. Don’t let the 41-10 loss to Clemson fool you. The The Yellow Jackets hung with the Tigers for most of the contest before imploding in the second half. Take the points.

2022 College Football Week 3 Pick: Georgia Tech

Penn State Nittany Lions vs. Auburn Tigers

  • When: Saturday, September 17th, 2022. 3:30pm EST.
  • Where: Jordan-Hare Stadium, Auburn, AL
  • College Football Odds: Penn State (-3) // Auburn (+3)

Penn State is a good team. Auburn isn’t. So although both of these squads are undefeated and even though this happens at Auburn, the Nittany Lions cover.

2022 College Football Week 3 Pick: Penn State

Mississippi State Bulldogs vs. LSU Tigers

  • When: Saturday, September 17th, 2022. 6:00pm EST.
  • Where: Tiger Stadium, Baton Rouge, LA
  • College Football Odds: Mississippi State (-3) // LSU (+3)

After losing to Florida State in their first game, 1-1 LSU bounced back with a quality 65-17 win over Southern. The victory proved LSU could score. But it also proved LSU isn’t a great football team.

Southern isn’t even one of the better FCS teams. Mississippi State beat Arizona 39-17 a week after the Wildcats dusted San Diego State on the road. Miss State also put a beating on Memphis in their first game of the season. Bulldogs cover.

2022 College Football Week 3 Pick: Mississippi State

Miami Hurricanes vs. Texas A&M Aggies

  • When: Saturday, September 17th, 2022. 9:00pm EST.
  • Where: Tiger Stadium, Baton Rouge, LA
  • College Football Odds: Mississippi State (-3) // LSU (+3)

In 2 games, Texas A&M is 0-2 against the spread. The Aggies couldn’t cover as a -35.5 favorite against Sam Houston State in their first game. Then in their last contest, the Aggies lost straight up to App State as a -18 chalk. Maybe, A&M just isn’t as good as so many believed they were.

Miami beat Southern Miss 30-7 in their last game. The Canes are a solid group with a strong defensive line. Miami can win this straight up. Taking the points is a no-brainer.

2022 College Football Week 3 Pick: Miami

Fresno State Bulldogs vs. USC Trojans

  • When: Saturday, September 17th, 2022. 10:30pm EST.
  • Where: Los Angeles Memorial Coliseum, Los Angeles, CA
  • College Football Odds: Fresno State (+13) // LSU (-13)

The line undervalues USC big time. The Trojans have beaten Rice 66-14 and Stanford 41-28 in their two games. Both games were cover victories. Fresno State beat Cal Poly-Slo and lost to Oregon State at home in their 2 games so far this season. USC should beat the Bulldogs by at least 20 points. Trojans win and cover.

2022 College Football Week 3 Pick: USC

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*All stated odds are subject to change without prior notice.