2022 College Football Week 4 Odds, Overview & Picks

By Hank Blaine

We are through three weeks of the 2022 college football season and there are still a whopping 33 teams unbeaten and that includes Kansas, Duke, Rutgers, Indiana, Syracuse and Tulane. Huh? We know at least one of those schools will lose this week when Kansas visits Duke. But that doesn’t make our list of top games in Week 4.

Before everything else, NitroBetting arms you with everything you need to kick things off on a positive note. Below, we provide event details, team and player statistics, and the latest NCAAF odds. More than that, we go the extra mile and share timely betting trends and predictions that help you secure the best picks. Check out for more sports betting odds and lines, exclusively at our online BTC sportsbook.

Top 2022 College Football Week 4 Games to Bet

Florida Gators vs. Tennessee Volunteers

  • When: Saturday, September 24th, 2022. 3:30pm EST.
  • Where: Neyland Stadium, Knoxville, TN
  • College Football Odds: Florida (+11) // Tennessee (-11)

CBS has this 3:30 p.m. ET matchup from the SEC and the Vols are one of those 33 unbeatens. For the first time since the 2016 season, ESPN College GameDay will originate from Knoxville. It marks the 10th time that Tennessee will host College GameDay. Including this Saturday, the past three times that Tennessee has hosted has been for a matchup with the Gators. It’s the ninth overall time GameDay is at a Florida-Tennessee game, tie for the third-most matchups on the show behind Alabama-LSU (11) and Ohio State-Penn State (11).

The Vols are off to their first 3-0 start since the 2016 season. Led by senior quarterback Hendon Hooker, UT has the nation’s fourth-highest scoring offense (52.0) and is third in the FBS in total offense (553.7). Hooker has thrown at least one touchdown pass in 15 straight games, which is second in program history behind only Heath Shuler (1992-94), who had 18. Receiver Jalin Hyatt has 18 catches for 267 yards and three touchdowns—already surpassing his career-bests in receiving yards (226) and receiving touchdown (2) totals from 2021.

Tennessee has now eclipsed 600 yards of total offense in a single game 17 times in program history. Three of those games have come during Coach Heupel’s first 16 games as head coach. Tennessee’s 63 points Saturday vs. Akron were a Heupel-era high and the most overall by a UT team since 2016. UT’s 57-point margin of victory was its highest since defeating Louisiana-Monroe 70-3 on Sept. 23, 2000. The Vols have now put up 60 or more points three times in the Heupel era.

Florida (2-1) was very lucky to avoid a home upset Saturday vs. a terrible South Florida team, prevailing 31 2-8. The Bulls’ Spencer Shrader missed a 49-yard field goal that would have tied the game with 23 seconds to play. UF managed to win despite a second straight tough game from sophomore quarterback Anthony Richardson, who completed 10 of 18 passes for 112 yards and threw two second-half interceptions, while being held to only 24 yards on seven rushing attempts.

Florida is 31-20 all-time vs. Tennessee, has won 16 of the last 17 meetings including an active five-game winning streak. Florida has won each of the last four matchups by 12 points or more. Florida has totaled 300-plus yards of offense against Tennessee in seven-straight games and in 12 of the last 13 meetings. The Gators also have rushed for 100-plus yards in 15 of the last 16 matchups.

2022 College Football Week 4 Pick: Tennessee ATS

Wisconsin Badgers vs. Ohio State Buckeyes

  • When: Saturday, September 24th, 2022. 7:30pm EST.
  • Where: Ohio Stadium, Columbus, OH
  • College Football Odds: Wisconsin (+18) // Ohio State (-18)

ABC prime-time game at 7:30 p.m. ET and could be a preview of the Big Ten title game – sure looks like the Buckeyes will get there. Since the Big Ten went to divisional play in 2011, Ohio State and Wisconsin own the two best conference records in the Big Ten. Each team has made six appearances in the Big Ten title game, facing each other in 2014, 2017 and 2019.

The last time Wisconsin opened the Big Ten season on the road against a Top-10 team was on Sept. 24, 2016 at No. 8 Michigan State. The Badgers defeated the Spartans, 30-6, in East Lansing and finished that season ranked 9th in the country.

Hard to know how good the 2022 Badgers might be as they routed Illinois State and New Mexico State but lost at home to Washington State. Wisconsin has 1,436 yards of total offense, 781 through the air and 655 on the ground. Junior QB Graham Mertz has played his best football as a Badger during UW’s first 3 games. Mertz ranks 5th in the country in pass efficiency (190.9). Defensively, UW has given up an average of just 8.0 points per game, 8th-best in the country.

Ohio State (3-0) comes off a 77-21 rout of Toledo. Ohio State’s 763 total yards of offense were the second-most in school history in a single game. The record is 776 yards, set against Bowling Green in 2016. The Buckeyes had 482 passing yards vs. the Rockets, the third-most in a single game in school history. The record is 573 against Utah in the Rose Bowl last season and second is 499 vs. Northwestern in 2018. The 77 points and 763 total yards are both the highest for an Ohio State team in the Ryan Day era.

The Buckeyes scored touchdowns on 11-of-12 possessions before running out the clock to end the game. Ohio State’s streak of 64 consecutive games with 20-plus points scored ranks second all-time, overtaking USC’s 63 game streak from 2002-06. Oklahoma’s 69 game streak from 2016-21 is still the highwater mark. In 41 games under Ryan Day, Ohio State has scored 30-or-more points 33 times. Ohio State is 33-0 in those games and is 4-4 when being held to less than 30 points.

2022 College Football Week 4 Pick: Wisconsin ATS

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*All stated odds are subject to change without prior notice.

READ MORE: 2022 College Football Week 5 Odds, Overview & Picks