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2022 NFL Week 2 Fantasy Waiver Wire Picks

By Jeff Stinger

Football season is back, and so too are millions of fantasy football leagues worldwide. Week 1 had tons of stunning twists and turns. In turn, the fantasy football waiver wire is abuzz with free agents ready for the picking. Who are the most prominent names to look out for after one week of action on the digital and real-life gridirons?

Nitrobetting is ready to equip its bettors with the latest news, odds, and special features for the entire duration of the 2022 NFL season. This time, let’s take a closer look at the hottest waiver wire targets in fantasy football heading into Week 2.

Top Fantasy Football Waiver Wire Targets in 2022 NFL Week 2


Jameis Winston – Saints

  • Pct. Owned: 36.4%

Owners of Dark Prescott (out 6-8 weeks with a thumb injury) may have to resort to streaming a QB for a while, and New Orleans’ Jameis Winston is likely available on the waiver wire. Winston continued his promising career revival in The Big Easy with a turnover-free effort in Week 1, finishing with 269 passing yards and two touchdown passes.

The Week 2 matchup against the Buccaneers might be quite daunting, but we believe that Winston will be driven to seek revenge against his team’s heated division rivals. The former Heisman Trophy winner faced the Bucs in Week 7 of last season; the last game he played before suffering a season-ending injury that derailed his first full season as the starter in New Orleans.

Running Back

Jeff Wilson Jr. – 49ers

  • Pct. Owned: 3.5%

It wouldn’t be a typical NFL season without a Niners running back going down to injury. The latest casualty is Eli Mitchell, who’ll miss about two months of action with a knee injury. In turn, it’s up to Jeff Wilson Jr. once more to carry the torch for a strong San Fran rushing attack.

Wilson was the man on the 49ers’ shelf last season when Mitchell broke out as a rookie. This time around, the fourth-year undrafted back from North Texas will have another crack at putting up decent numbers as a decent flex start in PPR leagues moving forward. Wilson last saw action in the 2020 season, ending up with career-highs of 600 rushing yards, 113 receiving yards, and 10 offensive TDs.

Jaylen Warren – Steelers

  • Pct. Owned: 1.3%

Nobody is safe from the injury bug, as stud running back Najee Harris also suffered a scare late in the fourth quarter of the amazing Week 1 contest between the Steelers and Bengals. That being said, it’s time to pick up Harris’ handcuff in Jaylen Warren.

The undrafted rookie out of Oklahoma State impressed the Pittsburgh coaching staff and made the final cut of the team in stride. Warren now has the golden opportunity as the Steelers’ lead back option and will have a rather favorable matchup against the Patriots in Week 2. New England mustered up just seven points in the loss to Miami and will face an opportunistic Steel Curtain D (five forced turnovers in Week 1 against Cincy), which could result in more touches for Warren in general.

Wide Receiver

Curtis Samuel – Commanders

  • Pct. Owned: 8.4%

Carson Wentz’s debut in Washington was met with tons of praises after a four-TD performance in a win over the Jaguars. Wide receiver Jahan Dotson (two TD catches) was the biggest winner from Wentz’s offensive explosion, but Dotson is owned in more than half of fantasy leagues right now.

That being said, fellow wideout Curtis Samuel is one option out of this revived Commanders offense who’s available in a majority of fantasy waiver wire pools. Samuel led all Washington receivers Sunday with eight receptions, finishing with 55 receiving yards and a trip to the end zone. The Commanders have a rather favorable matchup in Week 2 as they travel to Detroit to take on the Lions. Washington is currently a (+2.5) underdog in the upcoming matchup, but we expect a shootout in the Motor City given what we’ve seen from the surprisingly competent offenses from the Commanders and Lions on opening week.

Devin Duvernay – Ravens

  • Pct. Owned: 2.4%

If Lamar Jackson’s three passing touchdowns in Week 1 were no flukes, then Baltimore wide receiver Devin Duvernay should be one of the more sought-after options on the waiver wire this week. Duvernay scored two touchdowns for the Ravens and hauled in all four of the passes that went his way for 54 receiving yards in the victory against the Jets.

One thing of note, though, is that managers have to be confident in the fleet-footed Jackson to significantly increase his passing production throughout the entire season. The All-Pro return specialist still has to compete for looks with the likes of star tight end mark Andrews and fellow young wideout Rashod Bateman. Nevertheless, Duvernay is a high-upside WR stash for deeper leagues be they standard or PPR.

Tight End

O.J. Howard – Texans

  • Pct. Owned: 0.3%

Former first-round pick O.J. Howard has seen all the highs and lows as a pro. He won a Super Bowl as a virtual non-factor on the Buccaneers’ offense, signed with Buffalo this offseason only to miss the Bills’ final cut, and is now languishing in a Texans franchise in full rebuild mode.

However, it appears as though Howard will play a huge role as an end zone threat for quarterback Davis Mills from what we’ve seen in Week 1. The 27-year-old out of ‘Bama caught all two of his passes for 38 yards and with both receptions leading to TDs during the baffling 20-20 tie contest against division rival Indianapolis. Tight end remains a shallow position in fantasy, which means taking a flyer on Howard is a sound move for fantasy managers with an extra spot on the bench.

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READ MORE: 2022 NFL Week 2 Odds, Overview & Picks