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2022 NFL Week 2 Odds, Overview & Picks

By Hank Blaine

The Los Angeles Chargers and Kansas City Chiefs kick off what promises to be an exciting NFL Week 2 on Thursday when KC hosts the Chargers. Both teams won their week 1 games, which makes the AFC West division rival an important contest. Which team grabs first place in the division?

On Sunday, Tom Brady and the Buccaneers hope to end a 4-game losing streak versus the Saints and New England searches for their first win of the season against the Steelers. Then on Monday, the NFL showcases four teams when the Titans travel to Buffalo to take on the Bills and the Eagles host the Vikings.

Check out the latest NFL odds, analysis, and free picks for eight of the best games happening in NFL Week 2.

Top 2022 NFL Week 2 Games to Bet

Los Angeles Chargers vs. Kansas City Chiefs

  • When: Thursday, September 15th, 2022. 8:15pm EST.
  • Where: GEHA Field at Arrowhead Stadium, Kansas City, MO
  • NFL Odds: Chargers (+4.5) // Chiefs (-4.5)

No doubt, the Chiefs looked spectacular in their 44-21 beat down of the Arizona Cardinals last Sunday. But we should put things in perspective. First, Kyler Murray had to run AZ’s offense without DeAndre Hopkins. Second, the Cardinals defense is a shell of what it was in the first half of the 2021 season.

The Chargers were on their way to an easy victory until Derek Carr rallied the Raiders. LAC held on for the win. The Bolts have a roster as talented as Kansas City’s. 4 points are too many to give up to a conference contender.

2022 NFL Week 2 Pick: Los Angeles Chargers

Washington Commanders vs. Detroit Lions

  • When: Sunday, September 18th, 2022. 1:00pm EST.
  • Where: Ford Field, Detroit, MI
  • NFL Odds: Commanders (+2.5) // Lions (-2.5)

The Jaguars had D.C. on the ropes. Washington rallied for the win, but almost losing to Jacksonville at home is not a good sign.

Detroit had the Eagles on the ropes. Philadelphia rallied to tie the game in regulation and then kicked a field goal in overtime to win. Motor City quarterback Jared Goff is playing better than Commanders QB Carson Wentz. The Lions should handle Washington and cover the spread.

2022 NFL Week 2 Pick: Detroit Lions

Tampa Bay Buccaneers vs. New Orleans Saints

  • When: Sunday, September 18th, 2022. 1:00pm EST.
  • Where: Soldier Field, Chicago, IL
  • NFL Odds: Buccaneers (-2.5) // Saints (+2.5)

Yes, the Saints had to rally down 16 points in the fourth quarter to beat the lowly Atlanta Falcons. And, yes, the Buccaneers cruised to a 19-3 win over the Dallas Cowboys. To be fair, though, New Orleans versus Atlanta is one of the great rivalries in football.

On Sunday, the Saints will be much tighter. Not only that, but New Orleans has a 4-game regular season SU win streak against the Bucs. New Orleans wins and covers at home.

2022 NFL Week 2 Pick: New Orleans Saints

New England Patriots vs. Pittsburgh Steelers

  • When: Sunday, September 18th, 2022. 1:00pm EST.
  • Where: Acrisure Stadium, Pittsburgh, PA
  • NFL Odds: Patriots (-1.5) // Steelers (+1.5)

Pittsburgh must play without T.J. Watt, who suffered a pectoral muscle injury in the Steelers inspiring victory over the Cincinnati Bengals in week 1. But even without Watt, Pittsburgh’s defense will play well. A bigger issue is on the offensive side of the ball where running back Najee Harris will play but he’s not one-hundred percent. The Patriots win and cover.

2022 NFL Week 2 Pick: New England Patriots

Indianapolis Colts vs. Jacksonville Jaguars

  • When: Sunday, September 18th, 2022. 1:00pm EST.
  • Where: TIAA Bank Field, Jacksonville, FL
  • NFL Odds: Colts (-4) // Jaguars (+4)

Indy quarterback Matt Ryan threw the ball a lot in the Colts 20-20 first game tie against the Houston Texans. He didn’t dominate, which could be a bad sign facing the Jaguars on the road.

Jacksonville should have beaten the Washington Commanders. The fact Jacksonville was so close at the end tells us the 2022 Jaguars are a much different squad than the 2021 version. Jacksonville will have a chance to win this straight up.

2022 NFL Week 2 Pick: Jacksonville Jaguars

Cincinnati Bengals vs. Dallas Cowboys

  • When: Sunday, September 18th, 2022. 4:25pm EST.
  • Where: Hard Rock Stadium, Arlington, TX
  • NFL Odds: Patriots (+3) // Dolphins (-3)

In NFL Week 1, Joe Burrow threw 4 picks, including a pick six on his first pass of the game, which is why the Bengals head into Dallas with an 0-1 record. Dallas looked terrible in the loss to the Buccaneers.

What’s worse is that Dak Prescott, the Cowboys’ QB, suffered a thumb injury that could keep him on the bench up to 8 weeks. The Boys are in disarray. All Joe Cool must do is be more careful with the football for Cincinnati to start winning games and covering spreads.

2022 NFL Week 2 Pick: Cincinnati Bengals

Tennessee Titans vs. Buffalo Bills

  • When: Monday, September 19th, 2022. 7:15pm EST.
  • Where: Highmark Stadium, Orchard Park, NYI
  • NFL Odds: Titans (+10) // Bills (-10)

Buffalo was electric in the Bills’ 31-10 win over the defending champion Rams last Thursday night. The Rams could get nothing going on offense. Eventually, Josh Allen took over the game.

Tennessee is a different animal. The Titans have a rushing attack led by bruising Derrick Henry. The Rams have nobody who can rush the ball. This spread is much too high. Tennessee covers.

2022 NFL Week 2 Pick: Tennessee Titans

Minnesota Vikings vs. Philadelphia Eagles

  • When: Monday, September 19th, 2022. 8:30pm EST.
  • Where: Lincoln Financial Field, Philadelphia, PA
  • NFL Odds: Vikings (+2) // Eagles (-2)

The Vikings beat rival Green Bay 23-7 in their first game while the Eagles had to rally for a 38-35 overtime victory against the Lions in their first contest.

Philly rushed for 216 yards, which is great but could hurt the Eagles in this. Jalen Hurts is going to have to throw the ball in this game because Minnesota’s offense does everything well.

It’s tough to believe Hurts keeps up with Vikings quarterback Kirk Cousins. Minnesota wins straight up.

2022 NFL Week 2 Pick: Minnesota Vikings

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*All stated odds are subject to change without prior notice.

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