2022 NFL Week 3 Odds, Overview & Picks

By Hank Blaine

After an inexplicable 0-24 loss to the Jacksonville Jaguars in week 2, the Indianapolis Colts are reeling. The Colts must figure things out quickly because on Sunday Patrick Mahomes and the Kansas City Chiefs are in town. Check out odds, analysis, and a free pick for Colts versus Chiefs as well as eight other terrific football matchups happening in NFL Week 3.

Check out the latest NFL odds, analysis, and free picks for seven of the best games happening in NFL Week 3.

Top 2022 NFL Week 3 Games to Bet

READ MORE: 2022 NFL Week 3 Fantasy Waiver Wire Picks

Pittsburgh Steelers vs. Cleveland Browns

  • When: Thursday, September 22nd, 2022. 8:15pm EST.
  • Where: FirstEnergy Stadium, Cleveland, OH
  • NFL Odds: Steelers (+4.5) // Browns (-4.5)

Pittsburgh’s offense isn’t playing well, but the defense is rock solid. The Steelers allow 18.5 points per game. Mike Tomlin is preaching bend but don’t break, which should work perfectly against the Browns. Also, Cleveland lost to the Jets at home in NFL Week 2. Doubtful the Browns are over that implosion.

2022 NFL Week 3 Pick: Pittsburgh Steelers

Kansas City Chiefs vs. Indianapolis Colts

  • When: Sunday, September 25th, 2022. 1:00pm EST.
  • Where: Lucas Oil Stadium, Indianapolis, IN
  • NFL Odds: Chiefs (-6.5) // Colts (+6.5)

The Colts rallied in their first game to tie the Houston Texans 20-20. After the draw, many NFL handicappers thought the Colts might bounce back with a big road win over the Jaguars. Not only did the Colts not win, but Indy failed to score a single point.

The Chiefs rallied to beat the Chargers in their second game. The Colts can bounce back with a cover, but at this point, Indianapolis is unplayable.

2022 NFL Week 3 Pick: Kansas City Chiefs

Buffalo Bills vs. Miami Dolphins

  • When: Sunday, September 25th, 2022. 1:00pm EST.
  • Where: Hard Rock Stadium, Miami Gardens, FL
  • NFL Odds: Bills (-5.5) // Dolphins (+5.5)

The Bills are dominating opponents. Buffalo marched into Inglewood and blasted the Rams 31-10. Then in their second game, Buffalo put a 41-7 beating onto the Tennessee Titans. So there’s a reason so many believe the Bills can beat the Dolphins by more than 5 points.

But Miami heads into this after a franchise making, come from behind, victory over the Ravens. The Fins are capable of hanging with Buffalo’s offense and Miami does get home field. The Dolphins cover.

2022 NFL Week 3 Pick: Miami Dolphins

Baltimore Ravens vs. New England Patriots

  • When: Sunday, September 25th, 2022. 1:00pm EST.
  • Where: Gillette Stadium, Foxborough, MA
  • NFL Odds: Ravens (-3) // Patriots (+3)

The Ravens will be out to prove the meltdown loss to Miami, where Baltimore allowed Tua Tagovailoa to dominate and the Fins to score 28 points in the fourth, was an anomaly. New England is the home team.

The Patriots beat a solid Steelers team in week 2. Bill Belichick figures to come up with a plan to temper Lamar Jackson’s influence. New England is the play.

2022 NFL Week 3 Pick: New England Patriots

Cincinnati Bengals vs. New York Jets

  • When: Sunday, September 25th, 2022. 1:00pm EST.
  • Where: Metlife Stadium, East Rutherford, NJ
  • NFL Odds: Bengals (-5) // Jets (+5)

Cincinnati blew a for sure win against the Steelers in NFL Week 1. Then in NFL Week 2, the Bengals gave up a lead to the Cowboys.

NYJ rallied to beat the Cleveland Browns in their last contest. The Bengals are a better team than Cleveland. It should all come together for the Bengals on Sunday. A blow out win is a real possibility.

2022 NFL Week 3 Pick: Cincinnati Bengals

Philadelphia Eagles vs. Washington Commanders

  • When: Sunday, September 25th, 2022. 1:00pm EST.
  • Where: FedExField, North Englewood, MD
  • NFL Odds: Eagles (-6.5) // Commanders (+6.5)

D.C. has no shot of stopping Philadelphia’s offense. The Commanders should be 0-2 instead of 1-1. After a lucky win against the Jaguars, Washington fell apart versus Detroit. Washington isn’t a good football team. So if you like the Eagles, jump on them ASAP.

2022 NFL Week 3 Pick: Philadelphia Eagles

Green Bay Packers vs. Tampa Bay Buccaneers

  • When: Sunday, September 25th, 2022. 4:25pm EST.
  • Where: Raymond James Stadium, Tampa, FL
  • NFL Odds: Packers (+2.5) // Buccaneers (-2.5)

The week’s top matchup pits a couple of conference contenders against each other. Green Bay got back on track with a 27-10 win over the rival Chicago Bears. Tampa Bay beat their biggest rivals, the Saints, in week 2. Tampa should win and cover, but TB might bounce in this after such an emotional victory. Green Bay gets the nod.

2022 NFL Week 3 Pick: Green Bay Packers

Dallas Cowboys vs. New York Giants

  • When: Monday, September 26th, 2022. 8:15pm EST.
  • Where: Metlife Stadium, East Rutherford, NJ
  • NFL Odds: Cowboys (+2.5) // Giants (-2.5)

Dallas quarterback Cooper Rush is one of the top backups in the NFL. Rush rallied the Cowboys for a victory against the Bengals. But the New York Giants are 2-0 and this happens at the Meadowlands. The G-Men continue their improbable undefeated season.

2022 NFL Week 3 Pick: New York Giants

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*All stated odds are subject to change without prior notice.

READ MORE: 2022 NFL Week 2 Fantasy Waiver Wire Picks