In NFL Week 10, the San Francisco 49ers head to Jacksonville to take on the Jaguars in what some feel is a Super Bowl 58 preview. Jacksonville is in the hunt for the AFC Playoff’s top seed. The Niners acquired former second pick in the NFL Draft Chase Young to shore up their defensive line. Which team wins the week’s top NFL matchup? Check out NFL odds, analysis, and free picks for every game on the NFL Week 10 schedule.

Top 2023 NFL Week 10 Games to Bet

Week 10 Power Rankings are IN pic.twitter.com/p24tzJZRUN

— NFL on FOX Podcast (@NFLonFOXPod) November 7, 2023

READ MORE: 2023 NFL Week 10 Sleeper Picks

Carolina Panthers vs. Chicago Bears

• When: Thursday, November 9th, 2023. 8:15pm EST.
• Where: Soldier Field, Chicago, IL
• NFL Odds: Panthers (+3.5) // Bears (-3.5)

Carolina may not win another game. The Panthers shouldn’t beat the Bears because Chicago has upgraded Justin Fields, who missed the last 2 games from doubtful to questionable. Even if Fields doesn’t play, the Panthers will struggle in this one. Chicago covers.

2023 NFL Week 10 Pick: Chicago Bears

Indianapolis Colts vs. New England Patriots

• When: Sunday, November 12th, 2023. 9:30am EST.
• Where: Frankfurt Stadium, Frankfurt
• NFL Odds: Colts (-1) // Patriots (+1)

The Patriots are a bad football team. New England struggles to move the football on offense. That puts too much pressure on the defense, which in turn leads to losses. Bill Belichick’s squad has lost 2 straight and the Colts have a great rushing attack. So the Patriots will lose their third straight.

2023 NFL Week 10 Pick: Indianapolis Colts

Tennessee Titans vs. Tampa Bay Buccaneers

• When: Sunday, November 12th, 2023. 1:00pm EST.
• Where: Raymond James Stadium, Tampa, FL
• NFL Odds: Titans (+1.5) // Buccaneers (-1.5)

Will the bleeding stop in Tampa? It might in the next few weeks, but it won’t on Sunday. Since starting the season winning 3-of-4, Tampa has now lost 4 straight. Tennessee is the overall better team and Baker Mayfield is starting to play like he’s got one foot in retirement.

2023 NFL Week 10 Pick: Tennessee Titans

New Orleans Saints vs. Minnesota Vikings

• When: Sunday, November 12th, 2023. 1:00pm EST.
• Where: Raymond James Stadium, Tampa, FL
• NFL Odds: Saints (-2.5) // Buccaneers (+2.5)

The Vikings have won 5-of-6 and 4 straight. But Minnesota faces one of the surging teams in the conference on Sunday. New Orleans has won 2 straight and are playing well on both sides of the ball. The Saints’ rushing attack will keep the Vikings’ defense on their heels while New Orleans’ defense should contain the electric Joshua Dobbs.

2023 NFL Week 10 Pick: New Orleans Saints

San Francisco 49ers vs. Jacksonville Jaguars

• When: Sunday, November 12th, 2023. 1:00pm EST.
• Where: EverBank Stadium, Jacksonville, FL
• NFL Odds: 49ers (-3) // Jaguars (+3)

It makes no sense why the 49ers are the chalk in this. For sure, San Francisco is a quality team. But Jacksonville is on a 5-game winning streak and boasts one of the NFL’s best turnover creating defenses. Trevor Lawrence and his mates have scored 23 or more in 4-of-5 and beat Pittsburgh 20-10 on the road in the last.

2023 NFL Week 10 Pick: Jacksonville Jaguars

Green Bay Packers vs. Pittsburgh Steelers

• When: Sunday, November 12th, 2023. 1:00pm EST.
• Where: EverBank Stadium, Jacksonville, FL
• NFL Odds: Packers (-3) // Steelers (+3)

The Steelers are the overall better team. Pittsburgh shouldn’t have much trouble shutting down the Packers’ defense. When Pittsburgh has the ball, the Steelers, who are 5-2 straight up in their last 7, will rush with success.

2023 NFL Week 10 Pick: Pittsburgh Steelers

Cleveland Browns vs. Baltimore Ravens

• When: Sunday, November 12th, 2023. 1:00pm EST.
• Where: M&T Bank Stadium, Baltimore, MD
• NFL Odds: Browns (+6) // Ravens (-6)

The Browns will bounce after the stunning 27-0 NFL Week 9 victory over the Arizona Cardinals. Cleveland is a decent team, but they take on the Ravens in Baltimore. The Ravens manage a big time win and cover.

2023 NFL Week 10 Pick: Baltimore Ravens

Houston Texans vs. Cincinnati Bengals

• When: Sunday, November 12th, 2023. 1:00pm EST.
• Where: M&T Bank Stadium, Baltimore, MD
• NFL Odds: Texans (+7) // Bengals (-7)

C.J. Stroud is the real deal. The man can play football. However, Stroud must beat the hottest team in football. Joe Burrow is going to torch the Texans’ secondary while Trey Hendrickson and Sam Hubbard collapse the pocket on Stroud.

2023 NFL Week 10 Pick: Cincinnati Bengals

Detroit Lions vs. L.A. Chargers

• When: Sunday, November 12th, 2023. 4:05pm EST.
• Where: SoFi Stadium, Inglewood, CA
• NFL Odds: Lions (+7) // Chargers (-7)

The Chargers looked great dominating the New York Jets. But here’s the thing, it was the Jets. The Detroit Lions are the overall better team and the Bolts don’t often win 2 straight. Laying the points on the road chalk makes sense.

2023 NFL Week 10 Pick: Detroit Lions

Atlanta Falcons vs. Arizona Cardinals

• When: Sunday, November 12th, 2023. 4:05pm EST.
• Where: State Farm Stadium, Glendale, AZ
• NFL Odds: Falcons (-1.5) // Cardinals (+1.5)

By trading Joshua Dobbs to Minnesota, Arizona has given up on the season. Clayton Tune isn’t ready to start at quarterback. The Cards don’t seem to care. The ATL prevails.

2023 NFL Week 10 Pick: Atlanta Falcons

New York Giants vs. Dallas Cowboys

• When: Sunday, November 12th, 2023. 4:25pm EST.
• Where: AT&T Stadium, Arlington, TX
• NFL Odds: Giants (+18) // Cowboys (-18)

16.5 points is a ton to give up. But the Giants’ top 2 quarterbacks are out for the season. Tyrod Taylor is on IR and Daniel Jones has a busted Achilles. The Boys feast via a 24-point victory.

2023 NFL Week 10 Pick: Dallas Cowboys

Washington Commanders vs. Seattle Seahawks

• When: Sunday, November 12th, 2023. 4:25pm EST.
• Where: Lumen Field, Seattle, WA
• NFL Odds: Commanders (+6.5) // Seahawks (-6.5)

After a couple of impressive victories, Seattle fell to earth in a 37-3 loss to the Washington Commanders. Seahawks QB Geno Smith got sacked 4 times and threw a pick. Smith completed less than 47% of his passes. The Commanders won’t pressure Smith nearly as much. So Seattle covers.

2023 NFL Week 10 Pick: Seattle Seahawks

New York Jets vs. Las Vegas Raiders

• When: Sunday, November 12th, 2023. 8:20pm EST.
• Where: Allegiant Stadium, Las Vegas, NV
• NFL Odds: Jets (+2.5) // Raiders (-2.5)

The 27-6 loss to the Chargers on Monday Night Football broke a 3-game Jets’ winning streak. Things don’t get easier for NYJ because the Raiders are motivated now that Antonio Pierce is calling the shots instead of Josh McDaniel. The Raiders eke out a 9-6 or possibly 6-3 victory and cover.

2023 NFL Week 10 Pick: Las Vegas Raiders

Denver Broncos vs. Buffalo Bills

• When: Monday, November 13th, 2023. 8:15pm EST.
• Where: Highmark Stadium, Orchard Park, NY
• NFL Odds: Broncos (+7.5) // Bills (-7.5)

Buffalo offers way too many points. In their 24-9 win over the Kansas City Chiefs in NFL Week 8, the Broncos played a complete game, keeping the Chiefs’ terrific defense on their heels and playing great D against Patrick Mahomes and KC’s offense.

Denver takes on the Bills after their bye. The Broncos have a shot to start a winning streak. Don’t think for a moment Russell Wilson and Sean Payton didn’t discuss that during the off week. Broncos can win this straight up.

2023 NFL Week 10 Pick: Denver Broncos

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