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2023 NFL Week 6 Odds, Overview & Picks

By Hank Blaine

The odds for NFL Week 6 are out. Kansas City kicks off the action a -10.5 chalk when the Chiefs tackle the Denver Broncos on Thursday. Then on Sunday, San Francisco is a -5.5 road chalk against Cleveland. On Monday, Dallas hopes to get back on the winning track when the Boys throw down against the Bolts at SoFi a -2 road favorite. Check out NFL odds, analysis, and free picks for every game on the NFL Week 6 schedule.

Top 2023 NFL Week 6 Games to Bet

READ MORE: 2023 NFL Week 6 Sleeper Picks

Denver Broncos vs. Kansas City Chiefs

The line is massive, but the Denver Broncos are the worst team in the NFL. Some say the Cardinals. Some say the Bears.

Not us. The worst team in the NFL is one with Sean Payton as their head coach and Russell Wilson as their quarterback. The game has passed by Payton. Russ doesn’t seem to want to play anymore. Patrick Mahomes and Travis Kelce do. So the Chiefs roll.

2023 NFL Week 6 Pick: Kansas City Chiefs

Baltimore Ravens vs. Tennessee Titans

At first glance, the Ravens should cover this spread. Tennessee is terrible against the pass and Lamar Jackson has some weapons this season.

But Tennessee is tough to beat straight up at home, much less beat by 5 points. So although the game can go either way, we must take the points on the Titans.

2023 NFL Week 6 Pick: Tennessee Titans

Washington Commanders vs. Atlanta Falcons

Washington’s offense is actually decent. It’s their defense that’s a disaster. The Commanders allow an average of 32 points per game, ranking thirty-first in the league.

D.C. gives up 133.6 rushing yards on average per matchup. Bijan Robinson is going to have a lot of fun on Sunday.

2023 NFL Week 6 Pick: Atlanta Falcons

Minnesota Vikings vs. Chicago Bears

Why are the Vikings favorites versus the Bears even though this game happens in Chicago? Your guess is as good as ours.

Justin Jefferson is doubtful. So although Minnesota will move the ball and score points, they won’t score nearly as many as the Bears. Chicago should be the favorite, which means we’re taking the points for sure.

2023 NFL Week 6 Pick: Chicago Bears

Indianapolis Colts vs. Jacksonville Jaguars

The Jags have hit their stride. It took a couple of games, but Jacksonville is back to beating foes.

The Jags dusted Atlanta 23-7. Then in their next game, Jacksonville upset Buffalo 25-20. In NFL Week 1, Jax beat the Colts 31-21. We should see a similar score on Sunday in the rematch.

2023 NFL Week 6 Pick: Jacksonville Jaguars

San Francisco 49ers vs. Cleveland Browns

  • When: Sunday, October 15th, 2023. 1:00pm EST.
  • Where: Cleveland Browns Stadium, Cleveland, OH
  • NFL Odds: 49ers (-6) // Browns (+6)

The line leaped from Niners -3.5 to -5.5. The reason is simple. San Francisco’s offense is unstoppable and it’s impossible to beat their defense.

The Browns will put forth a decent effort. They will still lose by 14 to 20.

2023 NFL Week 6 Pick: San Francisco 49ers

Seattle Seahawks vs. Cincinnati Bengals

The Bengals finally played last Sunday. Cincinnati beat up a game but overmatched Arizona Cardinals squad. However, this Sunday, the Cincy Tigers take on one of the NFC’s better teams.

Seattle is playing great football. The fact the line hasn’t moved much means NFL bettors respect the Hawks.

2023 NFL Week 6 Pick: Seattle Seahawks

New Orleans Saints vs. Houston Texans

The Texans are much better than many believe. Still, Houston hosts a team that is on the verge of breaking out with a string of victories.

New Orleans thrashed New England 34-0. The Saints beat up the Patriots in every phase of the game. Houston rookie QB C.J. Stroud hasn’t yet faced a defense as good as the Saints’. Another blowout Saints victory could happen.

2023 NFL Week 6 Pick: New Orleans Saints

Carolina Panthers vs. Miami Dolphins

Carolina’s offensive line is a mess and the defense is missing their two top players, Xavier Woods and Shaq Thompson.

So it’s going to be difficult for the Panthers to contain Tua Tagovailoa, Tyreek Hill, and the rest of the Miami offense. The Fins score 42 on their way to an easy win and cover.

2023 NFL Week 6 Pick: Miami Dolphins

Carolina Panthers vs. Miami Dolphins

Carolina’s offensive line is a mess and the defense is missing their two top players, Xavier Woods and Shaq Thompson.

So it’s going to be difficult for the Panthers to contain Tua Tagovailoa, Tyreek Hill, and the rest of the Miami offense. The Fins score 42 on their way to an easy win and cover.

2023 NFL Week 6 Pick: Miami Dolphins

New England Patriots vs. Las Vegas Raiders

We’re about to write something we never thought we’d ever write: the Raiders are the play of the week.

No, seriously. Vegas should absolutely dominate the New England Patriots. The Pats’ defense is a mess. Jimmy G. will throw right, left, up the middle, and complete passes to six different recievers. New England’s offensive line is terrible. So Maxx Crosby should sack Mac Jones 4 times.

2023 NFL Week 6 Pick: Las Vegas Raiders

Detroit Lions vs. Tampa Bay Buccaneers

Tampa Bay allows 27% third-down efficiency from their opponents in the red zone. The Bucs are allowing 17 points per game.

Oh, and Baker Mayfield is playing great football. Detroit should be favored, but by 1.5, not by 3.

2023 NFL Week 6 Pick: Tampa Bay Buccaneers

Arizona Cardinals vs. Los Angeles Rams

Arizona has a solid defense. However, Cooper Kupp is back. What’s crazy is that even with Kupp in the lineup, superstar rookie Puka Nacua caught 6 passes for 57 yards and scored a TD versus the Eagles.

Kupp caught everything thrown his way. The Rams’ D should have a much easier time containing the Arizona offense than it did containing Philly’s.

2023 NFL Week 6 Pick: Los Angeles Rams

Philadelphia Eagles vs. New York Jets

  • When: Sunday, October 15th, 2023. 4:25pm EST.
  • Where: MetLife Stadium, East Rutherford, NJ
  • NFL Odds: Eagles (-7) // Jets (+7)

The Jets have a good defense, but this is a bad matchup. NYJ is one dimensional on offense.

If the Jets can’t rush the football, they can’t score points. Philly ranks first against the rush. So although the Jets D will do some good things on Sunday, Eagles cover.

2023 NFL Week 6 Pick: Los Angeles Rams

New York Giants vs. Buffalo Bills

The Giants average less than 13 points per game. The Giants defense allows over 30 points each contest.

The line is massive for sure. But Buffalo should have no trouble covering. A 21-point victory is a real possibility.

2023 NFL Week 6 Pick: Buffalo Bills

Dallas Cowboys vs. Los Angeles Chargers

Dallas’s 42-10 loss to San Francisco could have lasting effects in this. Teams don’t bounce back as well after a brutal loss like the one the Boys suffered.

On Monday, Big D travels to L.A. to take on the Chargers. Brock Purdy completed almost every single pass agianst the Dallas defense. Justin Herbert leads the league in total passing yards. So JH should carve up the Dallas D.

2023 NFL Week 6 Pick: Los Angeles Chargers

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READ MORE: 2023 NFL Week 6 Fantasy Football Waiver Wire Picks

*All stated odds are subject to change without prior notice.