49ers vs. Cowboys 2022 NFL Wild Card Odds, Preview & Pick

By Hank Blaine • January 14, 2022

The San Francisco 49ers rallied from being down 17 points in NFL Week 18 to beat the rival Los Angeles Rams and secure a playoff spot. For their efforts, the Niners secured a date with NFC East division winner Dallas in one of Sunday’s most intriguing wild card games. Can the Cowboys win their first playoff game since 2018?

NitroBetting presents a comprehensive preview of the 49ers vs. Cowboys game down below. Find event details, team and player stats, the latest NFL betting odds, trends, and predictions.

49ers vs. Cowboys Game Information

When: Sunday, January 16, 2022, 4:30 PM ET
Where: AT&T Stadium, Arlington, TX
TV: CBS
Radio: KNBR 680 (49ers) / KRLD-FM 105.3 THE FAN (Cowboys)
Live Stream: NFL Network, NFL League Pass
NFL Odds: 49ers (+3) / Cowboys (-3)

Why Bet on the San Francisco 49ers?

The 49ers were down 0-17 early against the Rams. All San Francisco did was rally for an improbable 27-24 overtime victory. Often when a team rallies for a win, a switch turns and that team puts together a string of victories. Not only that, but San Francisco has playoff experience.

The 49ers won the NFC in 2019 and battled the Kansas City Chiefs in the 2020 Super Bowl. Also, Deebo Samuel is impossible to cover. The running back-wide receiver can do it all. Finally, the Niners’ defense is healthier heading into the NFL Playoffs than it has been all season long.

Why Bet on the Dallas Cowboys?

Dallas has been one of the most consistent teams both straight up and against the spread this season. The Cowboys went 12-5 straight up and 13-4 ATS. The Cowboys went 5-1 ATS in their last 6 regular season games. Also, the Boys leads the NFL in yards per game, 407, and points per game, 31.2.

In addition to having the best offense in the league, Dallas also has the most opportunistic defense. Led by rookie Micah Parsons and end DeMarcus Lawrence, the Boys took the ball away 34 times this season, ranking first in the takeaway category.

49ers vs. Cowboys Betting Trends

Patriots are 4-1 ATS in the last 5 playoff road games.
Patriots are 5-2 ATS in the last 7 games following a straight up loss.
The total went over in 9 of New England’s last 13 games.
Bills are 11-5-2 ATS in the last 18 games as a home favorite.
Bills are 1-3-1 ATS in the last 5 games following a ATS win.
The total went over in 7 of Buffalo’s last 9 games played on a Saturday.

49ers vs. Cowboys Expert Betting Predictions

On paper, it looks as if Dallas should dominate. But in reality, the San Francisco 49ers offer overlay odds. Dallas got to beat up teams like the New York Giants, the Washington Football Team, the New Orleans Saints with an injured Taysom Hill at quarterback, and the Philadelphia Eagles whose main goal was to make sure nobody got hurt. No wonder the Cowboys looked fantastic down the stretch. When facing a good football team, the Arizona Cardinals in Week 17, the Cowboys imploded, losing 22-25. San Francisco’s defense is almost one-hundred percent healthy.

There’s no player on SF’s team listed as doubtful. Only tackle Trent Williams, running back Elijah Mitchell, linebacker Azeez Al-Shaair, and strong safety Jaquiski Tartt are listed as questionable. All four players should start, which means the Cowboys will face the San Francisco 49ers team that was the fourth choice to win the Super Bowl before the season began. Dallas is a good team, no doubt. But the 49ers are better. Backing San Francisco SU is the play.

Check out our latest sports betting guides for the 2022 NFL Regular Season. Stay tuned for more Football previews and articles and don’t forget to check out the latest football betting odds at our online Bitcoin sportsbook.

*All odds stated are subject to change without prior notice.