49ers vs. Rams 2022 NFL Week 8 Odds, Preview & Pick

By Jeff Stinger

The second of two scheduled meetings between the San Francisco 49ers and the Los Angeles Rams is just days away, as the former looks to upend its division rival yet again in their annual regular-season matchups. The 49ers are slipping in the standings, though, and the Rams are coming off their bye more refreshed and ready to put their regular-season slump against the Niners to rest.

Nitrobetting is ready to equip its bettors with the latest news, NFL betting odds, and special features for the entire duration of the 2022 NFL season. This time, let’s take a closer look at the upcoming Week 8 divisional showdown between the San Francisco 49ers and the Los Angeles Rams.

49ers vs. Rams Game Information

  • When: Sunday, October 30, 2022, 4:25 PM ET
  • Where: SoFi Stadium, Inglewood, CA
  • TV: FOX
  • Radio: KNBR 680 AM (49ers) // KSPN 710 AM (Rams)
  • Live Stream: NFL Game Pass
  • NFL Odds: 49ers (-1.5) // Rams (+1.5)

READ MORE: Broncos vs. Jaguars 2022 NFL Week 8 Odds, Preview & Pick

Why Bet on the San Francisco 49ers?

The San Francisco 49ers made all sorts of headlines entering Week 7 after they announced the signing of star running back Christian McCaffrey from the Panthers. Unfortunately, McCaffrey’s debut in San Fran was spoiled as the Niners ran into the buzzsaw that was the Kansas City Chiefs. KC obliterated them to the tune of a 44-23 beating in Santa Clara this past Sunday to hand them their second consecutive loss.

San Francisco had a top-two defense prior to getting blown out by the Chiefs as the cracks are starting to show for the team. The likes of Dre Greenlaw, Arik Armstead, Jason Verrett, and Samson Ebukam are all hobbled and questionable to play in Week 8, which could pose more problems for the D.

Why Bet on the Los Angeles Rams?

A win before heading into the bye is just what the Los Angeles Rams needed to hit the proverbial reset button. The defending Super Bowl champions are merely 3-3 through the first six weeks of the season, with one of those defeats coming at the hands of the very same Niners that they’ll be facing this coming Sunday.

At the end of Week 6, the Rams committed the most turnovers in the league with 13 gimmes to the opposition no thanks to the baffling play under center from Matthew Stafford. The 14-year veteran only has one start this season wherein he didn’t throw an interception. On the bright side, Stafford is still averaging over 250 passing yards per game to keep Los Angeles’ offense without a reliable running game humming along.

It’s been feast or famine for LA’s defense as well. The Rams are allowing the fifth-fewest yards to opponents on average this season but are just middle of the road in scoring defense (21.0 PAPG). They have to be prepared for another run-heavy attack from the Niners in Week 8 and they’ll be glad to find out that they’re the ninth-best team in the NFL against the run at 104.2 rushing yards allowed per contest.

Ravens vs. Buccaneers Betting Trends

  • The 49ers are 1-3 on the road this season (SU/ATS).
  • The Niners have won seven straight regular-season meetings against the Rams (6-1 ATS).
  • The totals went under in three of San Fran’s last four road games.
  • The Rams are 8-3 at home since the start of the previous season (5-6 ATS).
  • The Rams are 5-2 in their last seven games against their division rivals (4-3 ATS).
  • The totals went under in five of LA’s last six home games, including the playoffs.

Ravens vs. Buccaneers Expert Betting Predictions

The entire NFC West has been so unpredictable this season that this revisited rivalry is more of a toss-up now than ever. Although the Niners have had a good track record on their side going up against their interstate archnemesis, their laundry list of injuries is very concerning. That being said, the well-rested Rams should get their revenge against the 49ers at least for one week.

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*All stated odds are subject to change without prior notice.