Bills vs. Chargers 2023 NFL Week 16 Odds, Preview & Pick

By Hank Blaine • December 21, 2023

The Buffalo Bills are on a roll, which is bad news for their Saturday night opponent, the L.A. Chargers. The Bills have won two straight against good teams, Kansas City and Dallas. Buffalofaces a Bolts side that let go of head coach Brandon Staley and their general manager. Will the Chargers play with more enthusiasm now that Staley is no longer with the team? Or will Buffalo dominate reeling LAC? Check out NFL odds, analysis, and a free pick for Bills at Chargers.

Buffalo Bills vs. Los Angeles Chargers Game Information

Preppin' for the Chargers. #BUFvsLAC | #BillsMafia
— Buffalo Bills (@BuffaloBills) December 21, 2023

When: Saturday, December 23rd, 2023. 8:00pm EST.
Where: SoFi Stadium, Inglewood, CA
TV: Peacock
Radio: WGR 550 AM (Bills) // ALT 98.7 FM (Chargers)
Live Stream: NFL+
NFL Odds: Bills (-12) // Chargers (+12)

Why Bet on the Buffalo Bills?

The Bills defense has been fantastic. Patrick Mahomes and the Chiefs could only score 17 in a huge 20-17 Buffalo road win.

Then in NFL Week 15, the Bills stepped it up against Dak Prescott and the Dallas Cowboys, holding the Cowboys to 10 points in a 31-10 victory. What’s impressive about the win over the Cowboys is that in the week before, Prescott had torched Philadelphia’s defense for 271 yards and 2 TDs and Dallas had scored 33 points.

On Saturday, Buffalo faces a Chargers team without Justin Herbert, without Mike Williams, and with a banged up offensive line. The Bills D should continue their domination.

Josh Allen and his mates have begun to pick things up on the offensive end. The Bills dropped 32 against the Jets in a win. Even though they lost to Philly, Buffalo scored 34.

The Bills dropped 20 against Kansas City and then last Sunday versus the Cowboys, Buffalo switched it up, going to a run first offense. James Cook responded with 179 yards on 25 carries and scored a TD.

Cook’s ability to run with the football means the Bills are flexible. They can now do whatever they want on offense.

Why Bet on the Los Angeles Chargers?

The Chargers D didn’t play well versus Denver in a loss. LAC allowed the Broncos to score 24 points in a 24-7 defeat.

But although allowing the Broncos to score 24 isn’t great, what the Chargers gave up to the Raiders was downright unbelievable. The Raiders, yes, the Raiders scored 63 points against the Chargers in a 63-21 Las Vegas victory.

Aidan O’Connell played like Ken Stabler and Zamir White looked like Marcus Allen. It was the worst performance by a Chargers defense in, well, history. The 63 points explains why Brandon Staley no longer coaches the L.A. Chargers.

Justin Herbert is on IR, which explains why the Chargers’ offense has played so poorly in recent games. When healthy, Herbert is one of the better quarterbacks in the NFL.

So losing Herbert was a massive loss. Easton Stick just isn’t good enough to move the football against decent defenses. The Chargers scored 21 against the Raiders but that was after Vegas had jumped out to a 42-0 lead.

Bills vs. Chargers Betting Trends

Buffalo is 3-7 ATS in their last 10 games.
The Bills are 13-7 SU in their last 20 games.
The totals went under in 6 of Buffalo’s last 7 games.
Los Angeles is 1-5 ATS in their last 6 games.
The Chargers are 1-5 SU in their last 6 games.
The totals went under in 10 of LA Chargers’ last 12 games.

Bills vs. Chargers Expert Betting Predictions

It’s impossible for the Bolts to play worse against Buffalo than they did versus the Vegas Raiders. But that doesn’t mean the Chargers keep this close.

Buffalo is rolling. The Bills didn’t just beat Kansas City, but they blasted Dallas, destroying the Cowboys with their rushing attack.

On Saturday, the Chargers must defense against the pass and the run, which will lead to another LAC blowout loss. The Chargers’ season is over. Don’t expect LAC to step it up against one of the hottest teams in the league. Buffalo covers.

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*All stated odds are subject to change without prior notice.