Rams vs. 49ers 2022 NFL Week 4 Odds, Preview & Pick

By Hank Blaine • September 30, 2022

NFC West rivals Los Angeles and San Francisco throw down on Monday night when Matthew Stafford leads the Rams to the Bay Area to take on Jimmy Garoppolo and the 49ers. The Rams hope to push their record to 3-1 while San Francisco wants to get back to .500. Which team prevails?

Nitrobetting is ready to equip its bettors with the latest news, NFL betting odds, and special features for the entire duration of the 2022 NFL season. This time, let’s take a closer look at the upcoming Week 4 showdown between the Los Angeles Rams and the San Francisco 49ers.

Rams vs. 49ers Game Information

Rams week.

???? @ESPNNFL #BeatLA x #MNF pic.twitter.com/ZTaZxGttkG
— San Francisco 49ers (@49ers) September 29, 2022

When: Monday, October 3, 2022, 8:20 PM ET
Where: Levi’s Stadium, Santa Clara, CA
TV: ESPN
Radio: KSPN 710 AM (Rams) // KNBR 680 AM (49ers)
Live Stream: NFL Game Pass
NFL Odds: Rams (+2) // 49ers (-2)

Why Bet on the Los Angeles Rams?

Los Angeles averages 306.3 yards per game, ranking twenty-fifth in the league. The Rams are a much better passing team than they are a rushing team. Matthew Stafford averages 234 passing yards per game.

The Rams only rush for 72.3 yards per. The low rushing average ranks LAR thirtieth in the NFL. The Rams average 20.3 points per game. The Rams have turned the ball over 7 times in 3 games.

LAR’s defense ranks seventeenth in yards allowed per contest. Opponents average 93.7 rushingyards and 252.7 passing yards. The Rams give up 23.3 points each week. Los Angeles’ defense is opportunistic. The Rams have 7 takeaways this season.

Why Bet on the San Francisco 49ers?

So far this season, San Francisco’s offense has struggled. The 49ers average 15.7 points per game from 323.7 yards each contest. SF passes for 172.7 yards. The rushing attack has been more effective.

The 49ers average 151 yards per game on the ground. Brandon Aiyuk has the most receiving yards and Jeff Wilson Jr. has the most rushing yards. No doubt, San Francisco’s defense has carried the team. The 49ers rank second in total yards allowed.

Opponents average 227 yards per game versus the Niners’ D. The 49ers rank first in passing yards allowed per game. Opposing teams throw for 148.3 yards each contest. San Francisco allows 12.3 points per game, ranking third in the points allowed category.

Rams vs. 49ers Betting Trends

Rams are 4-1 ATS in the last 5 games on a Monday.
LAR is 1-4 ATS in the last 5 games.
Under is 4-1 in the Rams’ last 5 games.
49ers are 5-0 ATS in the last 5 games at home.
San Francisco is 14-4 ATS in the last 18 games on a Monday.
Under is 7-0 in the 49ers’ last 7 games on grass..

Rams vs. 49ers Expert Betting Predictions

Both teams are struggling on offense, which means we should turn to the defenses to find the winner against the spread. No doubt, the Rams have a good D. But so far this season, San Francisco’s defense is playing like it’s the NFL’s best unit. SF shuts down the run and the pass. When it comes to this game, Matthew Stafford hasn’t played well enough to move the ball effectively versus the league’s top D.

Not only that, but Staff has thrown 5 picks in 3 games, which means he’s not playing well. Finally, the trends point to an SF win and cover. The Rams are 0-5 against the spread in the last 5 meetings while the 49ers are 14-4 ATS in their last 18 Monday night games. This shouldn’t be anywhere close to the spread. The San Francisco 49ers win and cover by at least 6 points.

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*All stated odds are subject to change without prior notice.