2021 College Football Week 4 Preview, Odds and Picks

There’s a new Heisman Trophy betting favorite entering Week 4 of the 2021 college football season: Ole Miss quarterback Matt Corral has leapfrogged Alabama’s Bryce Young. Alas, the Rebels are off this week ahead of a showdown with the Tide on Oct. 2. Here are the two marquee matchups this week, not including Texas A&M-Arkansas, which we will preview individually.

Be sure to check out the latest 2021 College Football odds and lines at our online Bitcoin sportsbook before placing your bets this season!

Top 2021 College Football Week 4 Games to Bet On

READ MORE: 2021 College Football Week 4 Recap

No. 12 Notre Dame vs. No. 18 Wisconsin

  • When: Saturday, September 25th, 12:00pm ET
  • Where: Soldier Field, Chicago, Illinois
  • 2021 College Football Week 4 Odds: Wisconsin Badgers -5.5

It’s a noon start on Fox TV at a neutral site from Soldier Field in Chicago – technically part of the Shamrock Series. The Irish are 9-0 in Shamrock Series games since it began in 2009. This is the first Shamrock Series game since 2018, which was played at Yankee Stadium against Syracuse. ESPN College GameDay will be on site.

Of course, the current Irish starting quarterback is Wisconsin transfer Jack Coan. While the Irish were lucky to win their first two games, they looked much better this past Saturday in beating another Big Ten team (like Wisconsin) in Purdue, 27-13. It was Notre Dame’s 26th straight home win and 35th consecutive victory against an unranked opponent, a streak that dates back to the 2016 season.

Coan was 15-for-30 for 223 yards and two scores. He went over the 200-yard passing mark for the third straight game for the second time in his career. Defensively, Notre Dame has totaled 13 sacks over the first three games of the season. It is the most sacks to start a year since 1996, when the Irish also had 13 through the first three games. Irish coach Brian Kelly tied Knute Rockne for most wins all-time at Notre Dame (105).

Wisconsin lost its season opener at home to Penn State and had last week off after beating Eastern Michigan 34-7 on Sept. 11. The Badgers had 352 rushing yards and also dominated on defense by holding EMU to 92 total yards on offense and three first downs. The 38 plays were the fewest by a Badger opponent since South Florida ran 38 plays on Sept. 27, 2014. Wisconsin is now 20-6 under Paul Chryst in non-conference games.

The last time Notre Dame and Wisconsin met was Sept. 26, 1964. The Irish win 31-7 in Ara Parseghian’s first ever game coaching at Notre Dame.

2021 College Football Week 4 Pick: Notre Dame

Rutgers at No. 19 Michigan

  • When: Saturday, September 25th, 3:30pm ET
  • Where: Michigan Stadium, Ann Arbor, Michigan
  • 2021 College Football Week 4 Odds: Michigan -18.5

Few expected both schools to enter at 3-0, that’s for sure.

Rutgers trashed Delaware 45-13 in essentially a scrimmage in Week 3 to start 3-0 for the first time since 2012. Quarterback Noah Vedral went 21-for-26 for 323 yards, including a 62-yard touchdown pass to wide receiver Brandon Sanders and 28-yard touchdown toss to wide receiver Bo Melton.

Rutgers did not concede a turnover for the third-straight game. The Scarlet Knights last achieved the feat in 2009. It was the 31st game overall under Schiano without committing a turnover. Rutgers improved to 55-27 when scoring first under Schiano, 54-17 when having more sacks, 17-2 when scoring at least 40 points, 22-7 when converting at least 50 percent on third down and 26-2 when recording at least five sacks.

Michigan trounced Northern Illinois 63-10 last week. The Wolverines scored on each of their first nine drives and rushed for 373 yards and eight scores. Running back Blake Corum entered the game with the NCAA’s top average in all-purpose yards per game (221.5), and he produced 138 yards (125 yards rushing, 13 yards receiving). Corum has recorded multiple touchdowns in each of the three games to start the season. Michigan leads the nation in rushing at 350.3 yards per game.

The Wolverines are 6-1 all-time vs. Rutgers and have won the past six. It was 48-42 in triple overtime last year as the teams combined for nearly 1,000 yards of offense.

Since 1968, Michigan is 49-4 in Big Ten openers. It’s also Homecoming in Ann Arbor and U-M is 5-0 in Homecoming games under Jim Harbaugh.

2021 College Football Week 4 Pick: Rutgers

Check out our latest sports betting guides for the 2021 College Football season. Stay tuned for more Football previews and articles and don’t forget to check out the latest Football betting odds at our online Bitcoin sportsbook.

*All odds stated are subject to change without prior notice.