2022 NFL Week 1 Odds, Overview & Picks

By Hank Blaine

On September 8, the Buffalo Bills step onto the field at SoFi Stadium to take on the Los Angeles Rams. Buffalo enters the season an under 6-to-1 chalk to win Super Bowl 57. Will Buffalo show why so many are high on their title chances? Or will the defending champs put the Bills back in their place? See below for spread lines, analysis, and free picks for all 16 NFL games in week 1.

Top 2022 NFL Week 1 Games to Bet

Buffalo Bills vs. Los Angeles Rams

  • When: Thursday, September 8th, 2022. 8:20pm EST.
  • Where: SoFi Stadium, Los Angeles, CA
  • NFL Odds: Bills (-2.5) // Rams (+2.5)

Matthew Stafford said the elbow issue is no more, which is why the line should drop by at least a half a point before kickoff. But although Staff will be one-hundred percent, Leonard Floyd probably won’t and Allen can handle the Rams’ D.

2022 NFL Week 1 Pick: Buffalo Bills

New Orleans Saints vs. Atlanta Falcons

  • When: Sunday, September 11th, 2022. 1:00pm EST.
  • Where: Mercedes-Benz Stadium, Atlanta, GA
  • NFL Odds: Saints (-5.5) // Falcons (+5.5)

Atlanta offers ridiculous odds to win the Super Bowl. The Falcons won’t have success versus a strong Saints’ D while Jameis Winston should burn the Southern Birds like there’s no tomorrow.

2022 NFL Week 1 Pick: New Orleans Saints

San Francisco 49ers vs. Chicago Bears

  • When: Sunday, September 11th, 2022. 1:00pm EST.
  • Where: Soldier Field, Chicago, IL
  • NFL Odds: 49ers (-7) // Bears (+7)

The Bears don’t have a good enough offensive line to stop SF’s pass rush. The other issue? Trey Lance should have a field day versus a lousy Chicago defense.

2022 NFL Week 1 Pick: San Francisco 49ers

Baltimore Ravens vs. New York Jets

  • When: Sunday, September 11th, 2022. 1:00pm EST.
  • Where: MetLife Stadium, East Rutherford, NJ
  • NFL Odds: Ravens (-7) // Jets (+7)

-7 is too many points on a road squad in the first game of the season. The Ravens are the better team. But the Jets have two solid running backs in Michael Carter and Breece Hall. NYJ’s defense will be much better in 2022 than it was in 2021. Jets cover.

2022 NFL Week 1 Pick: New York Jets

Pittsburgh Steelers vs. Cincinnati Bengals

  • When: Sunday, September 11th, 2022. 1:00pm EST.
  • Where: Paycor Stadium, Cincinnati, OH
  • NFL Odds: Steelers (+6.5) // Bengals (-6.5)

This is a rivalry game. So the 6.5 points could mean something. Sure, the Steelers play for the first time without Big Ben under center. Yep, the Bengals have a retooled offensive line. But, again, this is a rivalry game and it’s in NFL Week 1.

2022 NFL Week 1 Pick: Pittsburgh Steelers

New England Patriots vs. Miami Dolphins

  • When: Sunday, September 11th, 2022. 1:00pm EST.
  • Where: Hard Rock Stadium, Miami Gardens, FL
  • NFL Odds: Patriots (+3) // Dolphins (-3)

Patriots versus Dolphins is one of the toughest week 1games to handicap. Both starting quarterbacks had to learn new offensive systems. On paper, New England isn’t close to having as much talent as Miami. But Bill Belichick will find a way to frustrate Fins quarterback Tua Tagovailoa. Pats can win this straight up.

2022 NFL Week 1 Pick: New England Patriots

Philadelphia Eagles vs. Detroit Lions

  • When: Sunday, September 11th, 2022. 1:00pm EST.
  • Where: Ford Field, Detroit, MI
  • NFL Odds: Eagles (-4) // Lions (+4)

We won’t know if Eagles starting quarterback Jalen Hurts has taken the next step until Sunday. To make matters more confusing, the Lions start one of the best defensive ends to come out of college in a long time, Michigan rookie Aidan Hutchinson. The extra point makes Detroit playable.

2022 NFL Week 1 Pick: Detroit Lions

Cleveland Browns vs. Carolina Panthers

  • When: Sunday, September 11th, 2022. 1:00pm EST.
  • Where: Bank of America Stadium, Charlotte, NC
  • NFL Odds: Browns (+2.5) // Panthers (-2.5)

The Panthers have a better roster than many believe. Things fell apart last season. They may not in 2022 unless Christian McCaffrey gets hurt again. If he’s healthy and Baker Mayfield plays well, Carolina will beat some teams and cover in some games. The Panthers should have no trouble covering less than 3 points at home versus a Browns team that may not have their minds on football.

2022 NFL Week 1 Pick: Carolina Panthers

Indianapolis Colts vs. Houston Texans

  • When: Sunday, September 11th, 2022. 1:00pm EST.
  • Where: NRG Stadium, Houston, TX
  • NFL Odds: Colts (-8) // Texans (+8)

Houston’s roster is the worst in the NFL. The Texans do have a solid, young, quarterback in Davis Mills. But Mills won’t do enough to keep this close.

2022 NFL Week 1 Pick: Houston Texans

Jacksonville Jaguars vs. Washington Commanders

  • When: Sunday, September 11th, 2022. 1:00pm EST.
  • Where: FedEx Field, North Englewood, MD
  • NFL Odds: Jaguars (+3.5) // Commanders (-3.5)

Man to man, the Jaguars’ roster has more talent. Jacksonville’s defense should be the top unit in this game. Also, how much better is D.C. quarterback Carson Wentz than Jaguars’ QB Trevor Lawrence? We’re guessing not much.

2022 NFL Week 1 Pick: Jacksonville Jaguars

New York Giants vs. Tennessee Titans

  • When: Sunday, September 11th, 2022. 4:25pm EST.
  • Where: Nissan Stadium, Nashville, TN
  • NFL Odds: Giants (+5.5) // Titans (-5.5)

The Titans have the overall better roster and the Giants have plenty of key players listed as questionable. However, NYG head coach Brian Daboll will call a game that keeps the Titans’ overrated defense on their heels. Don’t be surprised if the Giants win this on the money line.

2022 NFL Week 1 Pick: New York Giants

Green Bay Packers vs. Minnesota Vikings

  • When: Sunday, September 11th, 2022. 4:25pm EST.
  • Where: U.S. Bank Stadium, Minneapolis, MN
  • NFL Odds: Packers (-1.5) // Vikings (+1.5)

The Green Bay Packers could go through growing pains on offense while Minnesota will hit the ground running. The Vikings win a shootout.

2022 NFL Week 1 Pick: Minnesota Vikings

Las Vegas Raiders vs. Los Angeles Chargers

  • When: Sunday, September 11th, 2022. 4:25pm EST.
  • Where: SoFi Stadium, Los Angeles, CA
  • NFL Odds: Raiders (+3.5) // Chargers (-3.5)

The Raiders will start a seventh round draft pick at right tackle on Sunday. Vegas allowed 40 sacks last season. The Bolts have a fearsome defense. LAC easily covers the spread.

2022 NFL Week 1 Pick: Los Angeles Chargers

Kansas City Chiefs vs. Arizona Cardinals

  • When: Sunday, September 11th, 2022. 4:25pm EST.
  • Where: State Farm Stadium, Glendale, AZ
  • NFL Odds: Chiefs (-4.5) // Cardinals (+4.5)

Without DeAndre Hopkins, it’s difficult to see how the Arizona Cardinals keep up on the scoreboard. Not only is AZ missing DeAndre, but they also lost players on their defense. The Chiefs are the pick.

2022 NFL Week 1 Pick: Kansas City Chiefs

Tampa Bay Buccaneers vs. Dallas Cowboys

  • When: Sunday, September 11th, 2022. 8:20pm EST.
  • Where: AT&T Stadium, Arlington, TX
  • NFL Odds: Buccaneers (-1.5) // Cowboys (+1.5)

At +1.5, Dallas is the biggest overlay on the board. Tampa starts the season with three new starters along the offensive line. Tom Brady’s head was in a different space during training camp. The Boys win SU.

2022 NFL Week 1 Pick: Dallas Cowboys

Denver Broncos vs. Seattle Seahawks

  • When: Monday, September 11th, 2022. 8:15pm EST.
  • Where: Lumen Field, Seattle, WA
  • NFL Odds: Broncos (-6) // Seahawks (+6)

Seattle doesn’t have a good roster, but 6 points on the road is tough to lay. Seahawks starting quarterback Geno Smith doesn’t make a lot of mistakes and the Denver D could head into this over confident. Taking the points makes sense.

2022 NFL Week 1 Pick: Seattle Seahawks

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*All stated odds are subject to change without prior notice.