Bills vs. Bengals 2022 NFL Week 17 Odds, Preview & Pick

By Hank Blaine • December 28, 2022

It’s arguably the most important game in the AFC this regular season and also the final Monday night game of the season when the Buffalo Bills visit the Cincinnati Bengals in a possible AFC Championship Game preview and with huge tiebreaker ramifications.

This game will mark just the third in Monday Night Football history to involve two teams with 11-or-more wins. In 1997, San Francisco (12-2) defeated Denver (11-3), the Broncos’ last loss of that season en route to a Super Bowl XXXII victory. And in 1985, the Los Angeles Raiders (11-4) won the league’s final regular-season game, at the Los Angeles Rams (11-4).

Nitrobetting is ready to equip its bettors with the latest news, NFL odds, and special features for the entire duration of the 2022 NFL season. This time, let’s take a closer look at the upcoming week 17 clash between the Buffalo Bills and the Cincinnati Bengals.

Bills vs. Bengals Game Information

We're the only team in the AFC able to clinch the 1-seed this weekend.@Pepsi | #BillsMafia
— Buffalo Bills (@BuffaloBills) December 27, 2022

When: Monday, January 2, 2023, 8:30 PM ET
Where: Paycor Stadium, Cincinnati, OH
TV: CBS
Radio: WGR 550 AM (Bills) // 700 WLW (Bengals)
Live Stream: NFL Game Pass
NFL Odds: Bills (-1) // Bengals (+1)

Why Bet on the Buffalo Bills?

At 12-3, Buffalo is tied for the AFC’s best record with Kansas City – the Bills already have won the AFC East – and would be the top seed if it wins out because the Bills beat the Chiefs early this season. Earning the No. 1 seed could happen this week. Josh Allen & Co. must beat the Bengals on Monday Night Football and have the Chiefs lose at home to the Denver Broncos (which is very unlikely). The Bills are also the only team in the AFC that is able to clinch the 1 seed in Week 17.

Kansas City would need to win its final two games and the Bills to lose one of their final two games in order to leapfrog Buffalo in the AFC standings. The Bengals are also in play for the top seed but would need a win over Buffalo + a Chiefs loss to Denver.

Buffalo won its sixth straight game on Christmas Eve, 35-13 in Chicago. Josh Allen completed 15-of-26 attempts for 172 yards, two touchdowns and two interceptions, adding six rushes for 41 yards and a touchdown. Allen was as erratic as he’s been in a long time, throwing wildly several times in the first three quarters. Bears defenders dropped at least two other interceptions. The Bills still dominated with a strong running game.

Allen has totaled 173 combined passing and rushing touchdowns (135 passing, 38 rushing) since entering the NFL in 2018 and surpassed Hall of Famer Dan Marino (171 touchdowns) for the most combined passing and rushing touchdowns by a player in his first five seasons in NFL history.

Rookie James Cook rushed 11 times for 99 yards and a touchdown and caught one pass for nine yards. The 99 rushing yards and the 108 scrimmage yards were career highs. Cook has gone over 100 yards from scrimmage or scored a TD in three of the past four games. Devin Singletary rushed 12 times for 106 yards and a touchdown and had two catches for 19 yards. Singletary recorded a 33-yard touchdown run early in the third quarter that gave the Bills a lead they wouldn’t relinquish. The 100-yard effort was his first since Week 17 against the Falcons a year ago.

Why Bet on the Cincinnati Bengals?

Cincinnati (11-4) has clinched a playoff berth but not the AFC North yet. If the Bengals win out, they will be at least the No. 2 seed and AFC North champions. One Kansas City loss opens Cincinnati up to the top seed and a first-round bye. A loss on Monday means that Week 18 is an AFC North title game no matter what vs. the Ravens. Even if Baltimore loses on Sunday against Pittsburgh, they still would have a tied record with Cincinnati following a possible Week 18 win and will have swept the season series.

The Bengals won their seventh in a row on Christmas Eve, 22-18 at New England. The Bengals managed to pull out the win after Rhamondre Stevenson lost a goal-line fumble with less than a minute left. Joe Burrow completed 40-of-52 attempts for 375 yards, three touchdowns and two interceptions. He started the game hot, throwing for a TD on each of the Bengals’ first two drives of the game. Burrow cooled off a bit as the game went on, though. He threw an interception in the second quarter and a pick-six in the third quarter.

Starting right tackle La’el was diagnosed with ACL and MCL tears in his left knee after being hurt vs. the Pats and his season is over. Hakeem Adeniji is now in line to operate as Cincinnati’s starting right tackle for the remainder of the regular season as well as the postseason. Tight end Hayden Hurst has missed the past three games with a calf injury but is trending toward a return Monday. Through his first 12 appearances of the season, Hurst cobbled together a 48-400-2 receiving line on 63 targets.

Bills vs. Bengals Betting Trends

Bills are 2-5 ATS in the last 7 games following a straight up win.
Bills are 1-4 ATS in the last 5 games following a ATS win.
The total went under in 9 of Buffalo’s last 13 games.
Bengals are 5-0 ATS in the last 5 home games.
Bengals are 17-4 ATS in the last 21 games following a straight up win.
The total went under in 4 of Cincinnati’s last 5 games.

Bills vs. Bengals Expert Betting Predictions

Bengals 27, Bills 24.

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*All stated odds are subject to change without prior notice.