Bills vs. Chiefs 2021 NFL Week 5 Odds, Preview and Pick

By Hank Blaine • October 7, 2021

The marquee matchup in NFL Week 5 is the Sunday night game as the Buffalo Bills visit the Kansas City Chiefs – they are the two favorites to win the AFC and met in last season’s conference championship game, won by KC at home.

With more NFL action brewing, NitroBetting gets things going by providing a complete preview of the Bills vs. Chiefs game. Below, you can find essential information, including event details, team and player stats, the latest NFL betting odds, betting trends, and betting predictions. Check for the latest sports betting odds at our online BTC sportsbook.

Bills vs. Chiefs Game Information

When: Sunday, October 10, 2021, 8:20 PM ET
Where: GEHA Field at Arrowhead Stadium, Kansas City, Missouri
TV: NBC
Radio: WTMJ-AM (Bills) / 830 AM KLAA (Chiefs)
Live Stream:NFL Game Pass
NFL Odds: Buffalo Bills (+2.5) / Kansas City Chiefs (-2.5)

Why Bet on the Buffalo Bills?

Buffalo (3-1) won its third in a row Sunday, 40-0 over awful Houston. The Bills, who registered a shutout in Week 2 of Miami, are the third team since 1990 to record two shutouts in their first four games of a season, joining Baltimore in 2000 and Washington in 1991. Both those clubs won the Super Bowl.

The Bills currently have the best defense in the NFL allowing just 11 points a game and 216.8 total yards a game. They also have 11 takeaways, which is the most in the league. The Chiefs have the second-best offense in the NFL averaging 33.5 points per game and 427.5 total yards per game. The Bills will also have to figure out how to contain wide receiver Josh Gordon who was promoted to the active roster on Tuesday afternoon and will play.

Sunday will be Gordon’s first NFL game since Week 15 of the 2019 season. The Chiefs have been unable to find consistent production from a second receiver this year behind Hill. Mecole Hardman is third on the team with 123 receiving yards.

Kansas City doesn’t appear to have any serious injury concerns for this one, while Buffalo has four: Linebacker Matt Milano, defensive end Greg Rousseau, and cornerbacks Taron Johnson and Tre’Davious White. Safety Jordan Poyer, who missed last week’s game with an ankle injury, should play.

Why Bet on the Kansas City Chiefs?

Kansas City was 2-0 vs. Buffalo last season. In Week 6 on a Monday night in Buffalo, the Chiefs won 26-17. KC is known as a passing team behind Patrick Mahomes but rushed for 245 yards. Clyde Edwards-Helaire had the best game of his then-rookie season with 161 yards on 26 carries. Mahomes was an efficient 21-for-26 for 225 yards and two scores. Buffalo totals only 206 yards. Josh Allen was held to 122 passing with two TDs and a pick.

In the AFC title game in Kansas City, the Chiefs won 38-24. Mahomes threw for 325 yards and three scores. Travis Kelce finished with 13 catches for 118 yards and two touchdowns, and Tyreek Hill added nine catches for 172 yards, becoming the first duo in NFL history with consecutive games of at least 100 yards receiving each in a single postseason. For the Bills, Allen finished with 287 yards passing with two touchdowns and an interception. The game was never much in doubt.

Kansas City (2-2) snapped a two-game skid with a 42-30 win at Philadelphia last Sunday. Making his 50th career start, Mahomes had five touchdown passes and Hill had 11 receptions for 186 yards and three touchdowns. Mahomes became the fifth quarterback in NFL history to register at least three touchdown passes in each of his first four games of a season and the first player with four games of at least five touchdown passes in his first 50 career starts. Finally, Mahomes tallied his 31st career game with a passer rating north of 100.0 (131.0) to pass Len Dawson for the most such outings in franchise history.

Hill, who recorded his fifth career game with at least 180 receiving yards, is the fifth player with five games with at least 180 receiving yards in his first six seasons in NFL history. Since Week 12 of last season, Hill is the only player in the NFL to record 185+ yards and 3+ touchdowns in a single game, and he’s done so twice. Hill is one of just two players in NFL history to record multiple performances with 10+ receptions, 185+ yards and 3+ touchdowns, joining Jerry Rice.

Chiefs coach Andy Reid became the first NFL coach to win 100 games with two different teams (including playoffs). His 100th win with the Chiefs comes against the Eagles, which Reid coached to 140 wins (including playoffs).

Bills vs. Chiefs Betting Trends

Bills are 5-1 ATS in their last 6 road games.
Bills are 12-3 ATS in their last 15 games overall.
The total went under in 4 of Buffalo’s last 6 games.
Chiefs are 1-7 ATS in their last 8 home games.
Chiefs are 1-8 ATS in their last 9 vs. AFC.
The total went over in 4 of Kansas City’s last 6 games.

Bills vs. Chiefs Expert Betting Predictions

Pick: Chiefs 30, Bills 27

Check out our latest sports betting guides for the 2021 NFL Regular Season. Stay tuned for more Football previews and articles and don’t forget to check out the latest Football betting odds at our online Bitcoin sportsbook.

*All odds stated are subject to change without prior notice.