Top MLB Betting Picks of the Week (August 1, 2022)

By Jeff Stinger

This week is filled with a huge number of primetime MLB games that baseball betting fans will not want to miss out on. Not only do we have the longtime rivalry between the Dodgers and Giants resuming battle in the Bay Area, but there are also a couple of crucial Yankees contests on tap. Read on for our picks of the best MLB games to bet on and with one superb matchup chosen for each day of the working week ahead.

Top MLB Betting Picks of the Week (August 1st, 2022)

Los Angeles Dodgers vs. San Francisco Giants


  • When: Monday, August 1, 2022, 9:45 PM ET
  • Where: Oracle Park, San Francisco, CA
  • TV: MLB Network, NSBA, SNLA
  • Radio: MLB.TV, SiriusXM
  • MLB Betting Odds: TBA

The week kicks off with another pivotal clash between these two heated division rivals. The Dodgers are well ahead of the NL West field in the standings and are just one game behind the Yankees for the best record in the majors. Meanwhile, the Giants have been reeling and suffered a four-game sweep against the LA the last time they met the NL West leaders.

MLB Betting Pick: Dodgers

Seattle Mariners vs. New York Yankees


  • When: Tuesday, August 2, 2022, 7:05 PM ET
  • Where: Yankee Stadium, New York City, NY
  • TV: MLB Network, RTNW, YES
  • Radio: MLB.TV, SiriusXM
  • MLB Betting Odds: TBA

A duel between two 10-win starting pitchers in Seattle’s Logan Gilbert (10-4, 2.78 ERA) and Jameson Taillon (10-2, 3.72 ERA) is set for Tuesday night. The latter was sharper in his last start, with no runs allowed and eight strikeouts over six innings against the Royals. Taillon should give the edge to the Yanks.

MLB Betting Pick: Yankees

Boston Red Sox vs. Houston Astros


  • When: Wednesday, August 3, 2022, 2:10 PM ET
  • Where: Minute Maid Park, Houston, TX
  • TV: MLB Network, ATSW, NESN
  • Radio: MLB.TV, SiriusXM
  • MLB Betting Odds: TBA

Boston’s been on a slump and the team has been losing ground in the AL Wild Card race, dropping three of its last 10 as of this writing. This should be an easy victory for the Astros, who are 5-1 in their last six home games against the aforementioned playoff contenders Seattle and New York. Houston also has the third-best home record in the MLB at 33-15 to date.

MLB Betting Pick: Astros

Los Angeles Dodgers vs. San Francisco Giants


  • When: Thursday, August 4, 2022, 3:45 PM ET
  • Where: Oracle Park, San Francisco, CA
  • TV: MLB Network, NSBA, SNLA
  • Radio: MLB.TV, SiriusXM
  • MLB Betting Odds: TBA

The final meeting of the four-game set in San Fran should see a strong closing effort from the Giants regardless of the results from the first three games of the series. Although all-time Dodger great Clayton Kershaw (7-3, 2.66 ERA) is expected to start for LA, the Giants will counter with rising righty Jake Junis (4-2, 2.78 ERA), who has surrendered just one run over his last two starts (8.1 total innings).

MLB Betting Pick: Giants

New York Yankees vs. St. Louis Cardinals


  • When: Friday, August 5, 2022, 8:15 PM ET
  • Where: Busch Stadium, St. Louis, MO
  • TV: Amazon Prime, BSMW
  • Radio: MLB.TV, SiriusXM
  • MLB Betting Odds: TBA

A rare interleague showdown between two of the MLB’s most storied franchises will be on full display this Friday night. The Yanks and Cards have only played six games against one another since 2014, with New York having a 5-1 record in those contests and with wins in each of the last four. Although St. Louis is on the cusp of an NL Wild Card berth, the Yankees are just too much to handle as the best team in all of baseball right now.

MLB Betting Pick: Yankees

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*All stated odds are subject to change without prior notice.

READ MORE: Top MLB Betting Picks of the Week (August 8th, 2022)