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Rams vs. 49ers 2021 NFL Week 10 Odds, Preview and Pick

By Hank Blaine

The AFC West has the Sunday night prime-time spotlight to itself in NFL Week 10 as the Kansas City Chiefs visit the Las Vegas Raiders – the Chiefs’ first game in Sin City with fans allowed in attendance. They are short favorites.

NitroBetting is ready to equip its bettors with all the latest previews and odds for Week 10 of the 2021 NFL season. This time, we look at the rare interconference matchup between the Los Angeles Rams and the San Francisco 49ers. Find out more about the teams and the key players, event information, the latest NFL odds, and of course, helpful betting trends and expert betting predictions. Check out the latest sports betting odds and lines at our online Bitcoin sportsbook.

Rams vs. 49ers Game Information

  • When: Monday, November 15th, 2021, 8:15 PM ET
  • Where: Levi’s Stadium, Santa Clara, California
  • TV: ESPN
  • Radio: KSPN 710 AM (Rams) / KNBR 680 AM (49ers)
  • Live Stream:NFL Game Pass
  • NFL Odds: Rams (-3.5) / 49ers (+3.5)

READ MORE: Chiefs vs. Raiders 2021 NFL Week 10 Odds, Preview and Pick

Why Bet on the Los Angeles Rams?

The Rams average 399.3 yards per game. LAR scores 29 points per, which ranks fifth in the NFL. The key to Los Angeles’ offense is the line. If the line protects quarterback Matthew Stafford, he can pick apart any defense in the league. But if the O-line doesn’t give Staff enough time, he can make mistakes. The Titans got to Stafford in the Rams’ last game. For the most part this season, though, the Rams have given Stafford enough time to carve up secondaries without any problems.

Matthew Stafford and the Rams offense have gotten plenty of attention this season. But the reason Los Angeles is one of the favorites to win the Super Bowl this season is because of their defense.

The defense ranks twelfth in yards allowed each game. Opponents average just 348.2 yards each contest. The D gives up 21.8 points per. The Rams are especially adept at stopping the rush. Opposing teams average less than 100 yards a game versus the Rams stout run defense.

Why Bet on the San Francisco 49ers?

Known mainly as a defensive team, the San Francisco 49ers have leaned on their offense for most of this season. The Niners average over 113 rushing yards per game, ranking the 49ers first in the category.

San Francisco’s passing attack has flourished in 2021. The 49ers average 252.5 passing yards each contest. The strong rushing attack and stronger passing attack is why the 49ers score more than 23 points each time they step onto the field.

Although the 49ers have had to play with major injuries to a couple of star defenders, San Francisco ranks eighth in yards allowed. Opponents average just 338.1 yards each game versus the Niners’ D. San Francisco is better versus the pass, 206.5 yards each game, than run, 131.6 per contest. The 49ers allow over 25 points per game.

Rams vs. 49ers Betting Trends

  • Chiefs are 2-8 ATS in their last 10 games as a favorite.
  • Chiefs are 0-4 ATS in their last 4 vs. AFC West.
  • The total went under in 4 of Kansas City’s last 5 games.
  • Raiders are 5-1 ATS in their last 6 games as an underdog.
  • Raiders are 5-2 ATS vs. a team with a winning record.
  • The total went in 9 of Las Vegas’ last 13 games.

Rams vs. 49ers Expert Betting Predictions

Based on the latest injury news, this line makes the Rams an overlay. Forget Odell Beckham Jr. Whether Odell plays in this game or not, the result should be the same, a Los Angeles Rams victory.

San Francisco suffered another major injury this week. Tackle Mike McGlinchey is on I-R after suffering a torn quadricep. Also, Jimmy Garoppolo is listed as questionable because he’s got a leg injury.

So SF could be without one of their top offensive lineman and starting quarterback. That’s bad news for a 49ers team who will have to score close to 30 points to win this game. Matthew Stafford should bounce back from his horrible performance against the Titans while the San Francisco 49ers will struggle to move the ball. Rams win and cover.

NFL Week 10 Pick: Los Angeles Rams

Check out our latest sports betting guides for the 2021 NFL Regular Season. Stay tuned for more Football previews and articles and don’t forget to check out the latest Football betting odds at our online Bitcoin sportsbook.

*All odds stated are subject to change without prior notice.