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2022 NFL Week 4 Fantasy Waiver Wire Picks

By Jeff Stinger

Week 3 of the 2022 NFL season delivered yet another spectacular slate of football and we witnessed several unheralded players bust out with several huge performances. That being said, there are a lot of names to take note of as fantasy managers race to retool their rosters via the waiver wire in the days ahead.

Nitrobetting is ready to equip its bettors with the latest news, odds, and special features for the entire duration of the 2022 NFL season. This time, let’s take a closer look at the hottest waiver wire targets in fantasy football heading into Week 4.

Top Fantasy Football Waiver Wire Targets in 2022 NFL Week 4

READ MORE: 2022 NFL Week 4 Odds, Overview & Picks


Geno Smith – Seahawks

  • Pct. Owned: 6.7%

All things considered, Seattle quarterback Geno Smith has done a relatively fine job under center for a supposedly rebuilding franchise. The nine-year pro continues to make the most out of his late-career revival, throwing for 325 passing yards and two touchdown passes in Week 2 against Atlanta, and has put up at least 16 fantasy points in his first three starts.

Although the Seahawks are currently (+5.5) road dogs in their Week 4 matchup against the surprisingly competent Lions, they will face a Detroit defense that’s allowing an average of 31 points per game this season thus far. Fantasy owners of the injured Mac Jones, along with underperformers Jimmy Garoppolo, Matt Ryan, and Carson Wentz just to name a few, may want to pivot to a high-floor, low-ceiling QB option in Smith instead.

Running Back

Alexander Mattison – Vikings

  • Pct. Owned: 37.1%

With Vikings stud running back Dalvin Cook suffering a dislocated shoulder late in the Week 3 contest against the aforementioned Lions, fantasy leagues across the web will see yet another surge of waiver wire moves in an attempt to pick up Cook’s backup in Alexander Mattison.

As his fantasy ownership percentage would suggest, Mattison is one of the more prized backup running backs considering Cook’s long history with injury. The former third-round pick out of Boise State took over the starting RB role in the fourth quarter of the Week 3 game against Detroit, finding the end zone and carrying the ball seven times for 28 rushing yards. Mattison is quite the renowned pass-catching back as well, making him a high-priority acquisition in PPR leagues.

Khalil Herbert – Bears

  • Pct. Owned: 25.2%

Speaking of injuries, no player in Week 3 benefitted from an injury to his teammate than Chicago’s Khalil Herbert. Starting Bears running back David Montgomery left Sunday’s game against the Texans early with a knee/ankle issue, and Herbert stepped up in a big way, racking up 20 carries for 157 rushing yards and a pair of TD runs.

Herbert will be a hotter ticket on the waiver wire over Mattison given the more explosive performance by the former this past week. Nevertheless, These two backs will be nice additions to any fantasy rosters looking to add depth and possibly a better flex start in Week 4. The Bears will have a rather favorable matchup against the Giants ahead, which should also boost the 25-year-old’s value even as a short-term pickup across all fantasy league formats.

Wide Receiver

Zay Jones – Jaguars

  • Pct. Owned: 8.6%

At long last, Trevor Lawrence is starting to live up to his first-overall pick reputation. In turn, the Jaguars’ passing offense has looked better and no Jacksonville receiver has benefitted from the improved offense than young journeyman receiver Zay Jones, who hauled in 10 catches on 11 targets for 85 receiving yards and a TD in Week 3.

Jones has seen at least nine targets in two of his first three starts as a Jaguar and is widely regarded as Lawrence’s top option on the aerial attack to date. The former Bills and Raiders wideout is finally getting more looks after being the third or fourth option with his former teams and is a serviceable WR3/flex start in deeper leagues moving forward.

Mack Hollins – Raiders

  • Pct. Owned: 0.9%

Over in Vegas, no other wide receiver has come close to getting as many balls thrown his way from Derek Carr as Carr’s former collegiate teammate, Davante Adams. However, that trend could change seeing how former Super Bowl-winning wideout Mack Hollins erupted in Week 3.

With eight catches for 158 receiving yards and a trip to the end zone, Hollins is coming off his best performance since his rookie season in Philly back in 2017. Those targets are no fluke either, as the 29-year-old Maryland native saw eight targets in the Week 2 contest against the Cardinals as well. Hunter Renfrow will continue to threaten Hollins for targets in a relatively potent Raiders passing attack, but it’s hard to ignore that the latter is getting more looks than expected.

Tight End

Davis Njoku – Browns

  • Pct. Owned: 32.7%

Thanks to a strong running game, the Browns have been overperforming with backup QB Jacoby Brissett holding down the fort until Deshaun Watson makes his debut in Cleveland. That running game has, in turn, opened up the team’s passing attack, and with tight end David Njoku slowly becoming a bigger part of the offense in general.

It’s been quite a lackluster professional career for the former first-round selection Njoku, who has not had more than 640 receiving yards and four touchdowns in each of his first six seasons with the Browns. However, he saw a huge uptick in production in Week 3, finishing with nine receptions for 89 yards and a TD catch; arguably his best fantasy outing in years. Cleveland is currently a slight (-1.5) favorite to win on the road against the Falcons in Week 4 and Njoku is a nice plug-and-play pickup considering how shallow the pool of startable fantasy TEs always is.

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